(R)-3-羟基-gamma-丁内酯合成路线 （共 27 条）
反应条件
1: With 4 A molecular sieve; Rh2[N-benzene-fused phthaloyl-(S)-piperidinonate]4 in toluene T=-23°C; Mukaiyama aldol reaction; 12 h; 2: With hydrogenchloride in tetrahydrofuran T=23°C; 0.5 h; 3: With hydrogen; palladium on activated charcoal in methanol T=20°C; 2 h; Title compound not separated from byproducts;
参考文献
Heterocycles, , vol. 66, # 1 p. 567 - 578
反应条件
sodium tetrahydroborate; dimethylsulfide borane complex; trifluoroacetic acid Yield given. Multistep reaction;
参考文献
Tetrahedron, , vol. 52, # 24 p. 8297 - 8306
反应条件
hydrogenchloride 2 h; Heating;
参考文献
Tanaka, Akira; Yamashita, Kyohei
Synthesis, 1987 , # 6 p. 570 - 573
反应条件
trifluoroacetic acid in dichloromethane
参考文献
Journal of the Chemical Society, Chemical Communications, , # 6 p. 434 - 435
反应条件
Pseudomonas sp. DS-K-NR818 in water T=30°C; 40 h; pH 7.2; Title compound not separated from byproducts;
参考文献
Suzuki, Toshio; Idogaki, Hideaki; Kasai, Naoya
Tetrahedron Asymmetry, 1996 , vol. 7, # 11 p. 3109 - 3112
反应条件
1: With sodium hydroxide T=40°C; 2: With sodium hydroxide; alpha,alpha-dimethylbenzyl hydroperoxide T=70°C; 3: With sulfuric acid T=0 - 55°C; pH=1;
参考文献
Kumar, Pradeep; Deshmukh, Anis N.; Upadhyay, Rajesh K.; Gurjar, Mukund K.
Tetrahedron Asymmetry, 2005 , vol. 16, # 16 p. 2717 - 2721
反应条件
water T=30°C; pH=7.0; 1 h; Aqueous phosphate bufferEnzymatic reaction; Product distribution / selectivity;
参考文献
WO2007/35066 A1, ;
Page/Page column 5 ;
反应条件
water 0.666667 h; Enzymatic reaction; Product distribution / selectivity;
参考文献
WO2007/35066 A1, ;
Page/Page column 6 ;
反应条件
sulfuric acid 2.) H2O; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 46, # 21 p. 4319 - 4321
反应条件
sodium hydroxide; dihydrogen peroxide Oxidation;
参考文献
Journal of Organic Chemistry, , vol. 64, # 20 p. 7633 - 7634
