2-苯磺酰基-3,3-二(甲硫基)丙烯腈合成路线 （共 4 条）
反应条件
1: carbon disulfide; 2-(phenylsulfonyl)-acetonitrile With potassium hydroxide in 1,4-dioxane
T=20°C; 2 h; Inert atmosphere;
2: methyl iodide in 1,4-dioxane
3 h;
参考文献
Ivachtchenko, Alexandre V.; Dmitriev, Dmitri E.; Golovina, Elena S.; Kadieva, Madina G.; Koryakova, Angela G.; Kysil, Volodymyr M.; Mitkin, Oleg D.; Okun, Ilya M.; Tkachenko, Sergey E.; Vorobiev, Anton A.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 14 p. 5186 - 5196
反应条件
1: carbon disulfide; 2-(phenylsulfonyl)-acetonitrile With potassium hydroxide in ethanol
T=50°C; 1 h;
2: methyl iodide in N,N-dimethyl-formamide
T=50°C; 2 h;
参考文献
KYOWA HAKKO KOGYO CO., LTD.
Patent: EP1847530 A1, 2007 ;
Location in patent: Page/Page column 167 ;
反应条件
carbon disulfide; sodium hydroxide in water
参考文献
Hoffmann-La Roche Inc.
Patent: US4028089 A1, 1977 ;
参考文献
Smith Kline and French Laboratories Limited
Patent: US4013769 A1, 1977 ;
US 4013769 A
