4,5,6,7-四氢苯并[b]噻吩-4-胺合成路线 （共 7 条）
反应条件
ammonium acetate; sodium cyanoborohydride in methanol 168 h; Ambient temperature;
参考文献
Cauquil-Caubere, Isoline; Kamenka, Jean-Marc
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 11 p. 867 - 877
反应条件
diisobutylaluminium hydride in dichloromethane T=25°C; 2 h;
参考文献
Heterocycles, , vol. 48, # 5 p. 919 - 927
反应条件
1: 65 percent / H3PO4, Ac2O / 2.5 h / 120 °C 2: 88 percent / NH4OAc, NaBH3CN / methanol / 168 h / Ambient temperature View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 33, # 11 p. 867 - 877
反应条件
1: 85 percent / 98percent N2H4, KOH / bis-(2-hydroxy-ethyl) ether / 7 h / 180 °C 2: 65 percent / H3PO4, Ac2O / 2.5 h / 120 °C 3: 88 percent / NH4OAc, NaBH3CN / methanol / 168 h / Ambient temperature View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 33, # 11 p. 867 - 877
反应条件
T=185°C; Erhitzen des Reaktionsprodukts mit wss. Salzsaeure;
参考文献
Journal of Organic Chemistry, , vol. 18, p. 1511,1514
反应条件
sodium hydroxide in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; water
参考文献
American Cyanamid Company
Patent: US4036979 A1, 1977 ;
反应条件
hydrogenchloride in water
参考文献
American Cyanamid Company
Patent: US4036979 A1, 1977 ;
