2-[2-[2-[2-(2-叔丁氧羰基乙氧基)乙氧基]乙氧基]乙氧基]乙胺合成路线 （共 4 条）
反应条件
1: sodium / tetrahydrofuran / 24 h / 20 °C
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 48 h / 0 - 20 °C
3: sodium azide / N,N-dimethyl-formamide / 48 h / 50 °C
4: hydrogen / palladium 10 on activated carbon / methanol / 24 h / 20 °C / 760.05 Torr
View Scheme
参考文献
AMBRX, INC.; MIAO, Zhenwei; ATKINSON, Kyle, C.; BIROC, Sandra; BUSS, Timothy; COOK, Melissa; KRAYNOV, Vadim; MARSDEN, Robin; PINKSTAFF, Jason; SKIDMORE, Lillian; SUN, Ying; SZYDLIK, Angieszka; VALENTA, Ianina
Patent: WO2012/166560 A1, 2012 ;
WO 2012/166560 A1
反应条件
1: sodium / tetrahydrofuran / 24 h / 20 °C
2: N-ethyl-N,N-diisopropylamine / dichloromethane / 48 h / 0 - 20 °C
3: sodium azide / N,N-dimethyl-formamide / 48 h / 50 °C
4: hydrogen / palladium 10 on activated carbon / methanol / 24 h / 20 °C / 760.05 Torr
View Scheme
参考文献
AMBRX, INC.; MIAO, Zhenwei; ATKINSON, Kyle, C.; BIROC, Sandra; BUSS, Timothy; COOK, Melissa; KRAYNOV, Vadim; MARSDEN, Robin; PINKSTAFF, Jason; SKIDMORE, Lillian; SUN, Ying; SZYDLIK, Angieszka; VALENTA, Ianina
Patent: WO2012/166560 A1, 2012 ;
WO 2012/166560 A1
反应条件
1: N-ethyl-N,N-diisopropylamine / dichloromethane / 48 h / 0 - 20 °C
2: sodium azide / N,N-dimethyl-formamide / 48 h / 50 °C
3: hydrogen / palladium 10 on activated carbon / methanol / 24 h / 20 °C / 760.05 Torr
View Scheme
参考文献
AMBRX, INC.; MIAO, Zhenwei; ATKINSON, Kyle, C.; BIROC, Sandra; BUSS, Timothy; COOK, Melissa; KRAYNOV, Vadim; MARSDEN, Robin; PINKSTAFF, Jason; SKIDMORE, Lillian; SUN, Ying; SZYDLIK, Angieszka; VALENTA, Ianina
Patent: WO2012/166560 A1, 2012 ;
WO 2012/166560 A1
反应条件
1: sodium azide / N,N-dimethyl-formamide / 48 h / 50 °C
2: hydrogen / palladium 10 on activated carbon / methanol / 24 h / 20 °C / 760.05 Torr
View Scheme
参考文献
AMBRX, INC.; MIAO, Zhenwei; ATKINSON, Kyle, C.; BIROC, Sandra; BUSS, Timothy; COOK, Melissa; KRAYNOV, Vadim; MARSDEN, Robin; PINKSTAFF, Jason; SKIDMORE, Lillian; SUN, Ying; SZYDLIK, Angieszka; VALENTA, Ianina
Patent: WO2012/166560 A1, 2012 ;
WO 2012/166560 A1
