4-（3-氯丙基氧基）-3-甲氧基苯乙酮合成路线 （共 18 条）
反应条件
1: methyl iodide With magnesium in diethyl ether 0.5 h; Reflux; 2: 4-(3-chloropropoxy)-3-methoxybenzonitrile in toluene 3 h; Reflux; 3: With hydrogenchloride; water T=0°C; 6 h; Reflux;
参考文献
SYMED LABS LIMITED; MOHAN RAO, dodda; KRISHNA REDDY, pingili; VENKAT REDDY, buthukuri
Patent: WO2012/32532 A1, 2012 ;
Location in patent: Page/Page column 25; 26 ;
反应条件
potassium carbonate in acetonitrile T=20 - 80°C; 3 h;
参考文献
Kilaru, Ravendra Babu; Kuruva, Chandra Sekhar; Katla, Venkata Ramana; Chamarthi, Naga Raju
Asian Journal of Chemistry, 2013 , vol. 25, # 10 p. 5307 - 5310
反应条件
pyridine; chromium(VI) oxide in dichloromethane; toluene T=30°C; Product distribution / selectivity;
参考文献
SYMED LABS LIMITED; MOHAN RAO, dodda; KRISHNA REDDY, pingili; VENKAT REDDY, buthukuri
Patent: WO2012/32532 A1, 2012 ;
Location in patent: Page/Page column 20; 21 ;
反应条件
1: With copper(l) chloride in diethyl ether; toluene 1 h; Inert atmosphereReflux; 2: With sulfuric acid; water in toluene T=25°C; 2.25 h; Reflux; Product distribution / selectivity;
参考文献
SYMED LABS LIMITED; MOHAN RAO, dodda; KRISHNA REDDY, pingili; VENKAT REDDY, buthukuri
Patent: WO2012/32532 A1, 2012 ;
Location in patent: Page/Page column 26 ;
反应条件
tetrabutylammomium bromide; potassium carbonate in acetonitrile T=80°C; Industry scale;
参考文献
WO2012/164516 A1, ;
Page/Page column 4-5 ;
参考文献
US4366162 A1, ;
US 4366162 A
反应条件
potassium carbonate in acetone 20 h; Reflux;
参考文献
Organic Process Research and Development, , vol. 18, # 2 p. 342 - 348
反应条件
1.1: magnesium / diethyl ether / 1 h / Reflux 1.2: 6 h / 0 °C / Reflux 1.3: Cooling with ice 2.1: potassium dichromate; sulfuric acid / diethyl ether; water / 2 h / 10 - 20 °C View Scheme
反应条件
1.1: potassium carbonate / acetone / 0.08 h / 25 - 30 °C 1.2: 12.5 h / 25 - 30 °C / Reflux 2.1: magnesium / diethyl ether / 0.5 h / Reflux 2.2: 3 h / Reflux 2.3: 6 h / 0 °C / Reflux View Scheme
反应条件
1.1: potassium carbonate / acetone / Reflux 2.1: magnesium / diethyl ether / 1 h / Reflux 2.2: 6 h / 0 °C / Reflux 2.3: Cooling with ice 3.1: potassium dichromate; sulfuric acid / diethyl ether; water / 2 h / 10 - 20 °C View Scheme
