4-（3-氯丙基氧基）-3-甲氧基苯乙酮合成路线 （共 18 条）
反应条件
potassium carbonate; sodium bromide in water; N,N-dimethyl-formamide T=70°C; 20 h;
参考文献
ALEMBIC PHARMACEUTICALS LIMITED; RAMAN, Jayaraman, Venkat; RANE, Dnyandev; KEVAT, Jitendra; PATIL, Dattatray
Patent: WO2011/154860 A1, 2011 ;
Location in patent: Page/Page column 10-11 ;
反应条件
1: 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole monohydrochloride With sodium hydroxide in water T=25 - 30°C; 0.25 h; Industrial scaleGreen chemistry; 2: 1-[4-(3-chloropropoxy)-3-methoxyphenyl]ethanone in water T=25 - 30°C; 0.25 h; Industrial scaleGreen chemistry; 3: With tetrabutylammomium bromide in n-heptane; water T=65 - 70°C; Industrial scaleGreen chemistry; Reagent/catalystSolventTemperatureConcentrationTime;
参考文献
Solanki, Pavankumar V.; Uppelli, Sekhar Babu; Pandit, Bhushan S.; Mathad, Vijayavitthal T.
Organic Process Research and Development, 2014 , vol. 18, # 2 p. 342 - 348
反应条件
in N-methyl-acetamide
参考文献
Hoechst-Roussel Pharmaceuticals, Inc.
Patent: US5364866 A1, 1994 ;
反应条件
in N,N-dimethyl-formamide T=90°C; 16.1667 h;
参考文献
ARCH PHARMALABS LIMITED; ATHALYE, Shailesh, Shrikant; PARGHI, Kalpesh, Dalpat; RANBHAN, Kamlesh, Jayantilal; SARJEKAR, Pushpalata, Balkrishna
Patent: WO2012/153341 A1, 2012 ;
Location in patent: Page/Page column 26 ;
反应条件
diisopropylamine in methanol Reflux;
参考文献
ARCH PHARMALABS LIMITED; ATHALYE, Shailesh, Shrikant; PARGHI, Kalpesh, Dalpat; RANBHAN, Kamlesh, Jayantilal; SARJEKAR, Pushpalata, Balkrishna
Patent: WO2012/153341 A1, 2012 ;
Location in patent: Page/Page column 14-15; 19; 24 ;
反应条件
in N,N-dimethyl-formamide T=90°C; 970 h; Product distribution / selectivity;
参考文献
ARCH PHARMALABS LIMITED; ATHALYE, Shailesh, Shrikant; PARGHI, Kalpesh, Dalpat; RANBHAN, Kamlesh, Jayantilal; SARJEKAR, Pushpalata, Balkrishna
Patent: WO2012/153341 A1, 2012 ;
Location in patent: Page/Page column 22 ;
反应条件
1.1: potassium carbonate / acetonitrile / 60 - 85 °C 1.2: 0 - 30 °C 2.1: triethylamine / methanol View Scheme
参考文献
ORCHID CHEMICALS AND PHARMACEUTICALS LIMITED; REGURI, Buchi, Reddy; ARUNAGIRI, Muthulingam; YARROJU, Prasada, Chari; KASIYAPPAN GURUSAMY, Saravanakumar; PONNAPALLI, Kondalarao
Patent: WO2011/55188 A1, 2011 ;
反应条件
in N,N-dimethyl-formamide
参考文献
Organic Process Research and Development, , vol. 18, # 2 p. 342 - 348
