5-氨基-3,4-二氢-2(1H)-喹啉酮合成路线 （共 5 条）
反应条件
hydrogen; 10 Pd(OH)2/C in methanol T=20°C; P=22801.5 Torr; 48 h;
参考文献
Memory Pharmaceuticals Corporation
Patent: US2010/29629 A1, 2010 ;
Location in patent: Page/Page column 54-55 ;
US 20100029629 A1
反应条件
1: NH4OH*HCl; aq. NaOH / methanol / -10 - 20 °C 2: aq. NaOH / acetone / -10 - 20 °C 3: AlCl3 / CH2Cl2 / -10 - 20 °C 4: 95 percent / H2 / Pd/C / ethanol / 4 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 22 p. 6855 - 6869
反应条件
1: 100 percent / benzene / Heating 2: 78 percent / H2 / 10 percent Pd(OH)2-C / methanol / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 13 p. 1459 - 1462
反应条件
sodium nitrite; Copper(I)chloride in hydrogenchloride; ethanol; chloroform; water
参考文献
Otsuka Pharmaceutical Co., Ltd.
Patent: US4416884 A1, 1983 ;
反应条件
1: 2.) sodium carbonate; 3.) HCl / 1.) MeOH, reflux, 8 h; 2.) reflux, 8 h
2: 57 percent / triethylamine / dimethylformamide / 1 h / Ambient temperature
View Scheme
参考文献
Tominaga; Yo; Ogawa; Yamashita; Yabuuchi; Nakagawa
Chemical and Pharmaceutical Bulletin, 1984 , vol. 32, # 6 p. 2100 - 2110
