5,10-二氢-二苯并[b,e][1,4]二氮杂卓-11-酮合成路线 （共 43 条）
反应条件
potassium tert-butylate 1.) dioxane, reflux, 1 h, 2.) reflux, 4 h; Yield given. Multistep reaction;
参考文献
Novo Nordisk A/S
Patent: US5741791 A1, 1998 ;
反应条件
potassium tert-butylate in chloroform
参考文献
Japan Tobacco, Inc.
Patent: US6235730 B1, 2001 ;
反应条件
n-butyllithium 1.) hexane, dioxane, RT, 2 h, 2.) hexane, dioxane, reflux, 17 h; Yield given. Multistep reaction;
参考文献
Eberlein; Trummlitz; Engel; Schmidt; Pelzer; Mayer
Journal of Medicinal Chemistry, 1987 , vol. 30, # 8 p. 1378 - 1382
反应条件
molecular sieve; copper in chlorobenzene
T=130°C; Ullmann-Golgber condensation; 8 h;
参考文献
Technion Research and Development Foundation Ltd.
Patent: US6908915 B1, 2005 ;
Location in patent: Page/Page column 12-13 ;
反应条件
sodium formate; palladium 10 on activated carbon in water
T=20 - 50°C; 8 h;
参考文献
ENVIVO PHARMACEUTICALS, INC.; METHYLGENE INC.
Patent: WO2009/137499 A1, 2009 ;
Location in patent: Page/Page column 89 ;
WO 2009/137499 A1
反应条件
acetic acid in water
T=75°C; 3 h;
参考文献
COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH
Patent: US2010/228023 A1, 2010 ;
Location in patent: Page/Page column 3 ;
反应条件
1: H2 / 10 percent Pd/C / methanol
2: xylene / Heating
View Scheme
参考文献
Sum, Fuk-Wah; Dusza, John; Delos Santos, Efren; Grosu, George; Reich, Marvin; Du, Xumei; Albright, J. Donald; Chan, Peter; Coupet, Joseph; Ru, Xun; Mazandarani, Hossein; Saunders, Trina
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 13 p. 2195 - 2198
反应条件
tris-(dibenzylideneacetone)dipalladium(0); ammonia; caesium carbonate; [2'-(di-tert-butyl-phosphanyl)-biphenyl-2-yl]-dimethyl-amine in 1,4-dioxane
T=120°C; 24 h; Inert atmosphereMolecular sieve;
参考文献
Tsvelikhovsky, Dmitry; Buchwald, Stephen L.
Journal of the American Chemical Society, 2011 , vol. 133, # 36 p. 14228 - 14231
反应条件
tris-(dibenzylideneacetone)dipalladium(0); ammonia; caesium carbonate; [2'-(di-tert-butyl-phosphanyl)-biphenyl-2-yl]-dimethyl-amine in 1,4-dioxane
T=120°C; 24 h; Inert atmosphereMolecular sieve;
参考文献
Tsvelikhovsky, Dmitry; Buchwald, Stephen L.
Journal of the American Chemical Society, 2011 , vol. 133, # 36 p. 14228 - 14231
反应条件
copper(l) iodide; caesium carbonate; L-proline in dimethyl sulfoxide
T=120°C; 7 h;
参考文献
Majumdar; Ganai, Sintu
Synlett, 2011 , # 13 p. 1881 - 1887
