5,10-二氢-二苯并[b,e][1,4]二氮杂卓-11-酮合成路线 （共 43 条）
反应条件
iron in acetic acid
Heating;
参考文献
Bunce, Richard A.; Schammerhorn, James E.
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 4 p. 1031 - 1035
反应条件
copper(l) iodide; caesium carbonate; L-proline in dimethyl sulfoxide
T=120°C; 7 h;
参考文献
Majumdar; Ganai, Sintu
Synlett, 2011 , # 13 p. 1881 - 1887
反应条件
1: 43 percent / K2CO3 / Cu / dimethylformamide / 5 h / 140 °C
2: 90 percent / DVP-Fe, conc. HCl / aq. ethanol; H2O / 4 h / Heating
3: 83 percent / conc. H3PO4 / xylene / 12 h / 140 °C
View Scheme
参考文献
Ruger; Rohnert; Lohmann
Pharmazie, 1990 , vol. 45, # 8 p. 555 - 559
反应条件
tris-(dibenzylideneacetone)dipalladium(0); ammonia; caesium carbonate; [2'-(di-tert-butyl-phosphanyl)-biphenyl-2-yl]-dimethyl-amine in 1,4-dioxane
T=120°C; 6 h; Inert atmosphereMolecular sieve;
参考文献
Tsvelikhovsky, Dmitry; Buchwald, Stephen L.
Journal of the American Chemical Society, 2011 , vol. 133, # 36 p. 14228 - 14231
反应条件
1: 90 percent / K2CO3; copper-bronze / 6 h / 160 °C
2: 90 percent / iron / acetic acid / Heating
View Scheme
参考文献
Bunce, Richard A.; Schammerhorn, James E.
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 4 p. 1031 - 1035
反应条件
1: 90 percent / K2CO3; copper-bronze / 6 h / 160 °C
2: 90 percent / iron / acetic acid / Heating
View Scheme
参考文献
Bunce, Richard A.; Schammerhorn, James E.
Journal of Heterocyclic Chemistry, 2006 , vol. 43, # 4 p. 1031 - 1035
反应条件
1: Cu; K2CO3 / 200 °C
2: H2 / 10 percent Pd/C / methanol
3: xylene / Heating
View Scheme
参考文献
Sum, Fuk-Wah; Dusza, John; Delos Santos, Efren; Grosu, George; Reich, Marvin; Du, Xumei; Albright, J. Donald; Chan, Peter; Coupet, Joseph; Ru, Xun; Mazandarani, Hossein; Saunders, Trina
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 13 p. 2195 - 2198
反应条件
1: 43 percent / K2CO3 / Cu / dimethylformamide / 5 h / 140 °C
2: 90 percent / DVP-Fe, conc. HCl / aq. ethanol; H2O / 4 h / Heating
3: 83 percent / conc. H3PO4 / xylene / 12 h / 140 °C
View Scheme
参考文献
Ruger; Rohnert; Lohmann
Pharmazie, 1990 , vol. 45, # 8 p. 555 - 559
反应条件
1: 73 percent / dicyclohexyl carbodiimide / CH2Cl2
2: 77 percent / acetonitrile / 24 h / Heating
View Scheme
参考文献
Kraus, George A.; Liu, Peng
Tetrahedron Letters, 1995 , vol. 36, # 42 p. 7595 - 7598
反应条件
1: 73 percent / dicyclohexyl carbodiimide / CH2Cl2
2: 77 percent / acetonitrile / 24 h / Heating
View Scheme
参考文献
Kraus, George A.; Liu, Peng
Tetrahedron Letters, 1995 , vol. 36, # 42 p. 7595 - 7598
