5,10-二氢-二苯并[b,e][1,4]二氮杂卓-11-酮合成路线 （共 43 条）
反应条件
1: 70 percent / NaH / tetrahydrofuran
2: 73 percent / dicyclohexyl carbodiimide / CH2Cl2
3: 77 percent / acetonitrile / 24 h / Heating
View Scheme
参考文献
Kraus, George A.; Liu, Peng
Tetrahedron Letters, 1995 , vol. 36, # 42 p. 7595 - 7598
反应条件
1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / dichloromethane; water / 8 h / 20 °C / phase transfer catalysis
2: tin(ll) chloride / ethyl acetate / Reflux
3: copper(l) iodide; caesium carbonate; L-proline / dimethyl sulfoxide / 7 h / 120 °C
View Scheme
参考文献
Majumdar; Ganai, Sintu
Synlett, 2011 , # 13 p. 1881 - 1887
反应条件
1: tris-(dibenzylideneacetone)dipalladium(0); cyclohexyl BrettPhos; potassium carbonate / tert-butyl alcohol / 5 h / 100 °C / Inert atmosphere
2: tris-(dibenzylideneacetone)dipalladium(0); ammonia; caesium carbonate; [2'-(di-tert-butyl-phosphanyl)-biphenyl-2-yl]-dimethyl-amine / 1,4-dioxane / 24 h / 120 °C / Inert atmosphere; Molecular sieve
View Scheme
参考文献
Tsvelikhovsky, Dmitry; Buchwald, Stephen L.
Journal of the American Chemical Society, 2011 , vol. 133, # 36 p. 14228 - 14231
反应条件
1: tris-(dibenzylideneacetone)dipalladium(0); cyclohexyl BrettPhos; potassium carbonate / tert-butyl alcohol / 5 h / 100 °C / Inert atmosphere
2: tris-(dibenzylideneacetone)dipalladium(0); ammonia; caesium carbonate; [2'-(di-tert-butyl-phosphanyl)-biphenyl-2-yl]-dimethyl-amine / 1,4-dioxane / 24 h / 120 °C / Inert atmosphere; Molecular sieve
View Scheme
参考文献
Tsvelikhovsky, Dmitry; Buchwald, Stephen L.
Journal of the American Chemical Society, 2011 , vol. 133, # 36 p. 14228 - 14231
反应条件
1: tin(ll) chloride / ethyl acetate / Reflux
2: copper(l) iodide; caesium carbonate; L-proline / dimethyl sulfoxide / 7 h / 120 °C
View Scheme
参考文献
Majumdar; Ganai, Sintu
Synlett, 2011 , # 13 p. 1881 - 1887
反应条件
1: tin(ll) chloride / ethyl acetate / Reflux
2: copper(l) iodide; caesium carbonate; L-proline / dimethyl sulfoxide / 7 h / 120 °C
View Scheme
参考文献
Majumdar; Ganai, Sintu
Synlett, 2011 , # 13 p. 1881 - 1887
反应条件
1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / dichloromethane; water / 8 h / 20 °C / phase transfer catalysis
2: tin(ll) chloride / ethyl acetate / Reflux
3: copper(l) iodide; caesium carbonate; L-proline / dimethyl sulfoxide / 7 h / 120 °C
View Scheme
参考文献
Majumdar; Ganai, Sintu
Synlett, 2011 , # 13 p. 1881 - 1887
反应条件
1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / dichloromethane; water / 8 h / 20 °C / phase transfer catalysis
2: tin(ll) chloride / ethyl acetate / Reflux
3: copper(l) iodide; caesium carbonate; L-proline / dimethyl sulfoxide / 7 h / 120 °C
View Scheme
参考文献
Majumdar; Ganai, Sintu
Synlett, 2011 , # 13 p. 1881 - 1887
反应条件
1: hydrogenchloride / water / 2 h / |Reflux
2: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C
3: tin(ll) chloride; hydrogenchloride / 0.25 h / |Reflux
4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-(N,N-dimethlyamino)pyridine / acetonitrile / |Microwave irradiation
View Scheme
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
反应条件
1: nitric acid; sulfuric acid / 2 h / 70 °C
2: potassium permanganate; water / 8 h / |Reflux
3: palladium 10 on activated carbon / tetrahydrofuran / 24 h / 20 °C
4: sodium nitrite; hydrogenchloride; potassium iodide / dichloromethane / 4 h / 0 - 20 °C
5: potassium carbonate; copper(l) iodide / N,N-dimethyl-formamide / 4 h / 120 °C
6: tin(ll) chloride; hydrogenchloride / 0.25 h / |Reflux
7: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-(N,N-dimethlyamino)pyridine / acetonitrile / |Microwave irradiation
View Scheme
参考文献
Yu, Yongguo; Wu, Jianbo; Lei, Fan; Chen, Lei; Wan, Weili; Hai, Li; Guan, Mei; Wu, Yong
Letters in Drug Design and Discovery, 2013 , vol. 10, # 4 p. 369 - 373
