1-(6-甲氧基-1-萘基)乙烷-1-酮合成路线 （共 14 条）
反应条件
in diethyl ether
T=0°C; 24 h;
参考文献
Amin, Shantu; Hecht, Stephen S.; Hoffmann, Dietrich
Journal of Organic Chemistry, 1981 , vol. 46, # 11 p. 2394 - 2398
反应条件
ammonium chloride; sodium in tetrahydrofuran; ethanol; ammonia
4 h;
参考文献
Chatterjee, A.; Raychaudhuri, S. R.; Chatterjee, S. K.
Tetrahedron, 1981 , vol. 37, # 21 p. 3653 - 3660
反应条件
1: potassium carbonate / acetone / 50 °C
2: potassium hydroxide; water / tetrahydrofuran / 0.08 h / 100 °C
3: diethyl ether / 34 h / 0 °C
View Scheme
参考文献
Kisic, Andrea; Stephan, Michel; Mohar, Barbara
Organic Letters, 2013 , vol. 15, # 7 p. 1614 - 1617
反应条件
1: potassium hydroxide; water / tetrahydrofuran / 0.08 h / 100 °C
2: diethyl ether / 34 h / 0 °C
View Scheme
参考文献
Kisic, Andrea; Stephan, Michel; Mohar, Barbara
Organic Letters, 2013 , vol. 15, # 7 p. 1614 - 1617
反应条件
1: 85 percent / 2,3-dihydro-5,6-dicyano-1,4-benzoquinone / benzene / 2 h / Heating
2: 80 percent / NaOH, H2O / methanol / 20 h / Heating
3: 80 percent / diethyl ether / 24 h / 0 °C
View Scheme
参考文献
Amin, Shantu; Hecht, Stephen S.; Hoffmann, Dietrich
Journal of Organic Chemistry, 1981 , vol. 46, # 11 p. 2394 - 2398
反应条件
1: 80 percent / NaOH, H2O / methanol / 20 h / Heating
2: 80 percent / diethyl ether / 24 h / 0 °C
View Scheme
参考文献
Amin, Shantu; Hecht, Stephen S.; Hoffmann, Dietrich
Journal of Organic Chemistry, 1981 , vol. 46, # 11 p. 2394 - 2398
反应条件
1: 75 percent / AlCl3 (anhydr.) / nitrobenzene / 16 h / Ambient temperature
2: 53 percent / Na metal, ammonium chloride / ethanol; tetrahydrofuran; liquid ammonia / 4 h
View Scheme
参考文献
Chatterjee, A.; Raychaudhuri, S. R.; Chatterjee, S. K.
Tetrahedron, 1981 , vol. 37, # 21 p. 3653 - 3660
反应条件
ethanol; ammonia; sodium in tetrahydrofuran
0.5 h;
参考文献
Mejer, Stanislaw; Lusiak, Przemyslaw
Polish Journal of Chemistry, 1991 , vol. 65, # 12 p. 2279 - 2282
反应条件
sulfuric acid; acetic acid
T=75°C; 0.5 h;
参考文献
Gehring, Andrep.; Bracher, Franz
Synthesis (Germany), 2012 , vol. 44, # 15 p. 2441 - 2447
反应条件
1.1: tert.-butyl lithium / tetrahydrofuran; pentane / -65 - -20 °C / Inert atmosphere
1.2: 2 h / -35 - 20 °C / Inert atmosphere
2.1: hydrogenchloride / methanol; water / 0.08 h
3.1: sulfuric acid; acetic acid / 0.5 h / 75 °C
View Scheme
参考文献
Gehring, Andrep.; Bracher, Franz
Synthesis (Germany), 2012 , vol. 44, # 15 p. 2441 - 2447
