叔丁氧基二(二甲基氨基)甲烷合成路线 （共 92 条）
参考文献
Liebigs Annalen der Chemie, , # 3 p. 344 - 357
参考文献
Liebigs Annalen der Chemie, , # 3 p. 344 - 357
参考文献
Chemische Berichte, , vol. 104, p. 2709 - 2726
参考文献
American Cyanamid Company
Patent: US4521422 A1, 1985 ;
反应条件
hydrazine hydrate; nickel 1.) reflux, 3 h, 2.) THF, MeOH, RT, 30 min; Multistep reaction;
参考文献
Buchheit; Gamse; Giger; Hoyer; Klein; Kloeppner; Pfannkuche; Mattes
Journal of medicinal chemistry, 1995 , vol. 38, # 13 p. 2331 - 2338
反应条件
in toluene 6 h; Reflux;
参考文献
4SC Discovery GmbH
Patent: US2012/196862 A1, 2012 ;
Location in patent: Page/Page column 14 ;
反应条件
hydrazine hydrate; nickel 1.) reflux, 3 h, 2.) THF, MeOH, RT, 30 min; Multistep reaction;
参考文献
Buchheit; Gamse; Giger; Hoyer; Klein; Kloeppner; Pfannkuche; Mattes
Journal of medicinal chemistry, 1995 , vol. 38, # 13 p. 2331 - 2338
反应条件
in toluene T=120°C; 39 h;
参考文献
MERCK SHARP and DOHME CORP.; KUDUK, Scott, D.; CHANG, Ronald, K.; GRESHOCK, Thomas, J.
Patent: WO2012/47702 A1, 2012 ;
Location in patent: Page/Page column 32-33 ;
WO 2012/047702 A1
参考文献
Kantlehner, Willi; Mezger, Jochen; Stoyanov, Edmont V.; Leonhardt, Sylvia
Synthesis, 2008 , # 21 art. no. T07908SS, p. 3380 - 3382
反应条件
sodium periodate in water
参考文献
Pierre Fabre Medicament
Patent: US6020345 A1, 2000 ;
US 6020345 A
