N-(3-氧代-2,3-二氢-1H-茚-4-基)乙酰胺合成路线 （共 10 条）
反应条件
1: 91 percent / aq. HCl / 3 h / 90 °C 2: 64 percent / CuCl2; tert-butyl nitrite / acetonitrile / 0.17 h / 65 °C View Scheme
参考文献
Nguyen, Phong; Corpuz, Evelyn; Heidelbaugh, Todd M.; Chow, Ken; Garst, Michael E.
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 10195 - 10198
反应条件
1.1: 91 percent / aq. HCl / 3 h / 90 °C 2.1: HCl; NaNO2 / H2O; acetic acid / 0.08 h / 0 °C 2.2: 43 percent / KI / H2O; acetic acid / 1 h / 60 °C View Scheme
参考文献
Nguyen, Phong; Corpuz, Evelyn; Heidelbaugh, Todd M.; Chow, Ken; Garst, Michael E.
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 10195 - 10198
反应条件
hydrogenchloride in ethanol; water T=70°C; 3 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: WO2006/21544 A1, 2006 ;
Location in patent: Page/Page column 36-37 ;
WO 2006/021544 A1
反应条件
1: 91 percent / aq. HCl / 3 h / 90 °C 2: nitrosonium tetrafluoroborate / acetone / -15 °C 3: 0.25 g / toluene / 5.5 h / 84 °C View Scheme
参考文献
Nguyen, Phong; Corpuz, Evelyn; Heidelbaugh, Todd M.; Chow, Ken; Garst, Michael E.
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 10195 - 10198
反应条件
1.1: 91 percent / aq. HCl / 3 h / 90 °C 2.1: HBr; NaNO2 / ethanol; H2O / 0.25 h / 0 °C 2.2: 60 percent / CuBr; HBr / ethanol; H2O / 0.25 h / 95 °C View Scheme
参考文献
Nguyen, Phong; Corpuz, Evelyn; Heidelbaugh, Todd M.; Chow, Ken; Garst, Michael E.
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 10195 - 10198
反应条件
potassium permanganate; magnesium sulfate in water; acetone
T=0°C; 2 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: WO2006/21544 A1, 2006 ;
Location in patent: Page/Page column 36 ;
WO 2006/021544 A1
参考文献
Cignarella; Barlocco; Landriani; Folloni; Pinna; Sala; Germini
Farmaco, Edizione Scientifica, 1988 , vol. 43, # 2 p. 169 - 179
反应条件
1: 17 g / ethanol / 16 h / 20 °C
2: 14 g / potassium permanganate; MgSO4 / acetone; H2O / 16 h / 20 °C
View Scheme
参考文献
Nguyen, Phong; Corpuz, Evelyn; Heidelbaugh, Todd M.; Chow, Ken; Garst, Michael E.
Journal of Organic Chemistry, 2003 , vol. 68, # 26 p. 10195 - 10198
反应条件
1: aq. NaOH
2: (i) SOCl2, (ii) AlCl3
View Scheme
参考文献
Biggs; Casy; Chu; Coutts
Journal of Medicinal Chemistry, 1976 , vol. 19, # 4 p. 472 - 475
反应条件
(i) SOCl2, (ii) AlCl3; Multistep reaction;
参考文献
Biggs; Casy; Chu; Coutts
Journal of Medicinal Chemistry, 1976 , vol. 19, # 4 p. 472 - 475
