(2S)-吡咯烷-2-羧酸乙酯合成路线 (共 24 条)
反应条件
1: 77.2 percent / Et3N / benzene / Ambient temperature 2: 78.2 percent / NH3 / ethanol / Ambient temperature View Scheme
参考文献
Pharmaceutical Chemistry Journal, , vol. 18, # 12 p. 811 - 815
Khimiko-Farmatsevticheskii Zhurnal, , vol. 18, # 12 p. 1445 - 1448
反应条件
1: 15.7 percent / ethanol / 36 h 2: 55 percent / LiAlH4 / diethyl ether / 10 h / Heating View Scheme
参考文献
Nazarova, L. S.; Rozonov, Yu. B.; Likhosherstov, A. M.; Morozova, T. V.; Skoldinov, A. P.; et al.
Pharmaceutical Chemistry Journal, 1984 , vol. 18, # 12 p. 811 - 815
Khimiko-Farmatsevticheskii Zhurnal, 1984 , vol. 18, # 12 p. 1445 - 1448
反应条件
potassium carbonate in acetone T=25°C; 12 h;
参考文献
Haraguchi, Ryosuke; Matsubara, Seijiro
Organic Letters, 2013 , vol. 15, # 13 p. 3378 - 3380
反应条件
triethylamine in ethanol 4 h; Heating; Yield given;
参考文献
Enders, Dieter; Kipphardt, Helmut; Gerdes, Peter; Brena-Valle, Leonardo J.; Bhushan, Vidya
Bulletin des Societes Chimiques Belges, 1988 , vol. 97, # 8-9 p. 691 - 704
反应条件
1: triethylamine / ethanol / 4 h / Heating 2: 75 percent / diethyl ether / 2 h / Heating 3: 90 percent / H2 / 10 percent Pd/C / ethanol / Ambient temperature View Scheme
参考文献
Enders, Dieter; Kipphardt, Helmut; Gerdes, Peter; Brena-Valle, Leonardo J.; Bhushan, Vidya
Bulletin des Societes Chimiques Belges, 1988 , vol. 97, # 8-9 p. 691 - 704
参考文献
Takahashi, Hiroshi; Kawabata, Akihiro; Higashiyama, Kimio
Chemical & Pharmaceutical Bulletin, 1987 , vol. 35, # 4 p. 1604 - 1607
反应条件
1: triethylamine / ethanol / 4 h / Heating 2: 75 percent / diethyl ether / 2 h / Heating 3: 72 percent / Li, NH3 / diethyl ether; tetrahydrofuran / 3 h / -45 °C 4: 91 percent / H2 / 10 percent Pd/C / ethanol / 3 h / Heating View Scheme
参考文献
Enders, Dieter; Kipphardt, Helmut; Gerdes, Peter; Brena-Valle, Leonardo J.; Bhushan, Vidya
Bulletin des Societes Chimiques Belges, 1988 , vol. 97, # 8-9 p. 691 - 704
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Karrer; Portmann; Suter
Helvetica Chimica Acta, 1948 , vol. 31, p. 1617,1623
参考文献
Journal of the American Chemical Society, , vol. 77, p. 1522,1524
反应条件
in ethanol 6 h; Heating;
参考文献
McHugh, Michael; Proctor, George R.
Journal of Chemical Research, Miniprint, 1984 , # 8 p. 2230 - 2253