methanol in tetrahydrofuran; hexane T=20°C; 48 h;

trifluoroacetic acid in chloroform T=18°C; 2 h;

1.1: 96 percent / CH2Cl2; H2O / 15 h / 20 °C 2.1: 63 percent / DIBAL-H / toluene; hexane / 3 h / -78 °C 3.1: K2CO3 / methanol / 1 h / Heating 3.2: 82 percent / KOH / methanol / 6 h / Heating 4.1: 90 percent / 1,2-dichloro-benzene / 20 h / Heating 5.1: Et3N; CF3CH2OH / 72 h / 20 °C 5.2: 73 percent / Zn; NH4Cl / methanol / 10 h / 20 °C / sonication 6.1: 83 percent / PhI(OAc)2; KOH / 12 h / 20 °C 7.1: 96 percent / aq. AcOH / 8 h / 20 °C 8.1: 62 percent / TMSOTf; Et3N / CH2Cl2 / 1 h / 10 °C 9.1: 34 percent / MeOH / tetrahydrofuran; hexane / 48 h / 20 °C View Scheme

1.1: Et3N; CF3CH2OH / 72 h / 20 °C 1.2: 73 percent / Zn; NH4Cl / methanol / 10 h / 20 °C / sonication 2.1: 83 percent / PhI(OAc)2; KOH / 12 h / 20 °C 3.1: 96 percent / aq. AcOH / 8 h / 20 °C 4.1: 62 percent / TMSOTf; Et3N / CH2Cl2 / 1 h / 10 °C 5.1: 34 percent / MeOH / tetrahydrofuran; hexane / 48 h / 20 °C View Scheme

1.1: K2CO3 / methanol / 1 h / Heating 1.2: 82 percent / KOH / methanol / 6 h / Heating 2.1: 90 percent / 1,2-dichloro-benzene / 20 h / Heating 3.1: Et3N; CF3CH2OH / 72 h / 20 °C 3.2: 73 percent / Zn; NH4Cl / methanol / 10 h / 20 °C / sonication 4.1: 83 percent / PhI(OAc)2; KOH / 12 h / 20 °C 5.1: 96 percent / aq. AcOH / 8 h / 20 °C 6.1: 62 percent / TMSOTf; Et3N / CH2Cl2 / 1 h / 10 °C 7.1: 34 percent / MeOH / tetrahydrofuran; hexane / 48 h / 20 °C View Scheme

1.1: 63 percent / DIBAL-H / toluene; hexane / 3 h / -78 °C 2.1: K2CO3 / methanol / 1 h / Heating 2.2: 82 percent / KOH / methanol / 6 h / Heating 3.1: 90 percent / 1,2-dichloro-benzene / 20 h / Heating 4.1: Et3N; CF3CH2OH / 72 h / 20 °C 4.2: 73 percent / Zn; NH4Cl / methanol / 10 h / 20 °C / sonication 5.1: 83 percent / PhI(OAc)2; KOH / 12 h / 20 °C 6.1: 96 percent / aq. AcOH / 8 h / 20 °C 7.1: 62 percent / TMSOTf; Et3N / CH2Cl2 / 1 h / 10 °C 8.1: 34 percent / MeOH / tetrahydrofuran; hexane / 48 h / 20 °C View Scheme

1.1: 90 percent / 1,2-dichloro-benzene / 20 h / Heating 2.1: Et3N; CF3CH2OH / 72 h / 20 °C 2.2: 73 percent / Zn; NH4Cl / methanol / 10 h / 20 °C / sonication 3.1: 83 percent / PhI(OAc)2; KOH / 12 h / 20 °C 4.1: 96 percent / aq. AcOH / 8 h / 20 °C 5.1: 62 percent / TMSOTf; Et3N / CH2Cl2 / 1 h / 10 °C 6.1: 34 percent / MeOH / tetrahydrofuran; hexane / 48 h / 20 °C View Scheme

1: 83 percent / PhI(OAc)2; KOH / 12 h / 20 °C 2: 96 percent / aq. AcOH / 8 h / 20 °C 3: 62 percent / TMSOTf; Et3N / CH2Cl2 / 1 h / 10 °C 4: 34 percent / MeOH / tetrahydrofuran; hexane / 48 h / 20 °C View Scheme

1: 78 percent / hydrazine hydrate / tetrahydrofuran / 18 h / 25 °C 2: 70 percent / KOH / methanol; H2O / 30 h / 85 °C 3: 41 percent / methanol; tetrahydrofuran; hexane / 20 h / 25 °C View Scheme

1: 70 percent / KOH / methanol; H2O / 30 h / 85 °C 2: 41 percent / methanol; tetrahydrofuran; hexane / 20 h / 25 °C View Scheme