1-[(4-硝基苯基)甲基]哌嗪合成路线 （共 8 条）
反应条件
potassium carbonate in ethanol T=0°C; 1 h;
参考文献
Zhao, Yan-Fang; Liu, Zi-Jian; Zhai, Xin; Ge, Dan-Dan; Huang, Qiang; Gong, Ping
Chinese Chemical Letters, 2013 , vol. 24, # 5 p. 386 - 388
反应条件
sodium tris(acetoxy)borohydride in dichloromethane T=20°C; 18 h;
参考文献
Delarue; Girault; Maes; Debreu-Fontaine; Labaeid; Grellier; Sergheraert
Journal of Medicinal Chemistry, 2001 , vol. 44, # 17 p. 2827 - 2833
反应条件
in toluene T=85°C; 2 h;
参考文献
Capuano, Ben; Crosby, Ian T.; Lloyd, Edward J.; Taylor, David A.
Australian Journal of Chemistry, 2002 , vol. 55, # 9 p. 565 - 576
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 3 h;
参考文献
Tetrahedron, , vol. 63, # 51 p. 12786 - 12790
反应条件
1: polymer supported perruthenate / toluene / 2 h / 80 °C 2: polymer supported cyanoborohydride / methanol; toluene / 72 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 15 p. 2239 - 2241
反应条件
1: piperazine; piperazine Dihydrochloride in ethanol T=65°C; 1 h; 2: 4-nitrobenzyl chloride in ethanol T=78°C; 2 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 44, # 3 p. 1363 - 1368
反应条件
triethylamine in dichloromethane T=20°C;
参考文献
Archiv der Pharmazie, , vol. 333, # 8 p. 267 - 274
反应条件
1: Et3N / CH2Cl2 / 20 °C 2: H2 / 10 percent Pd/C / methanol / 4 h View Scheme
参考文献
Dannhardt, Gerd; Gruchalla, Markus V.; Kohl, Beate K.; Parsons
Archiv der Pharmazie, 2000 , vol. 333, # 8 p. 267 - 274
