4,4,4-三氟-1-(4-氟苯基)丁烷-1,3-二酮合成路线 （共 6 条）
反应条件
sodium methylate in tert-butyl methyl ether T=20°C; 3 h;
参考文献
Buettelmann, Bernd; Jakob-Roetne, Roland; Knust, Henner; Lucas, Matthew C.; Thomas, Andrew
Patent: US2009/143371 A1, 2009 ;
Location in patent: Page/Page column 39 ;
US 20090143371 A1
反应条件
2,2'-bi-1H-imidazole; copper (II) acetate monohydrate; potassium carbonate in dimethyl sulfoxide T=45°C; 5 h;
参考文献
Zhou, Chunmei; Zeng, Runsheng; Zou, Jianping
Chinese Journal of Chemistry, 2010 , vol. 28, # 2 p. 294 - 298
反应条件
in ethanol 20 h; Heating; Yield given;
参考文献
Sun, Changquan; O'Connor, Garry
Patent: US2005/222240 A1, 2005 ;
Location in patent: Page/Page column 4-5 ;
反应条件
hydrogenchloride in ethanol Reflux;
参考文献
Chiu, Hao-Chieh; Lee, Su-Lin; Kapuriya, Naval; Wang, Dasheng; Chen, Yi-Ru; Yu, Sung-Liang; Kulp, Samuel K.; Teng, Lee-Jene; Chen, Ching-Shih
Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 15 p. 4653 - 4660
反应条件
sulfuric acid in ethanol
参考文献
Sloop, Joseph C.; Bumgardner, Carl L.; Loehle, W. David
Journal of Fluorine Chemistry, 2002 , vol. 118, # 1-2 p. 135 - 147
反应条件
in ethanol
24 h; Heating;
参考文献
Uddin, Md. Jashim; Rao, P.N. Praveen; Knaus, Edward E.
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 23 p. 5273 - 5280
