1.1: aluminum tri-bromide / dichloromethane / 4 h / -40 - -15 °C / Large scale reaction 1.2: 0.5 h / 40 °C / Large scale reaction 1.3: 4 h / 40 °C / Large scale reaction 2.1: potassium hydroxide / methanol / 2 h / 18 - 25 °C / Large scale reaction 3.1: acetic anhydride / 135 - 140 °C / Large scale reaction 4.1: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / chlorobenzene / 70 - 95 °C / 300.03 Torr / Irradiation; Large scale reaction 5.1: sodium hydroxide / water; isopropyl alcohol / 77 - 82 °C / Large scale reaction 6.1: 5 Pd(II)/C(eggshell); formic acid; 3-Methylpyridine; triethylamine / water / 16 h / Reflux; Large scale reaction View Scheme

1: potassium hydroxide / methanol / 2 h / 18 - 25 °C / Large scale reaction 2: acetic anhydride / 135 - 140 °C / Large scale reaction 3: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / chlorobenzene / 70 - 95 °C / 300.03 Torr / Irradiation; Large scale reaction 4: sodium hydroxide / water; isopropyl alcohol / 77 - 82 °C / Large scale reaction 5: 5 Pd(II)/C(eggshell); formic acid; 3-Methylpyridine; triethylamine / water / 16 h / Reflux; Large scale reaction View Scheme

1: 98 percent / Pd(PPh3)2Cl2; CuI; (iPr)2EtN / 0.5 h / 90 °C 2: 36 percent / 1000 °C / 0.9 Torr / flash vacuum pyrolysis View Scheme

hydrogen in gas T=900°C; electrically heated vertical laboratory tubular furnace; Product distribution;

Heating; Product distribution;