4-氯-5-氟-7H-吡咯并[2,3-D]-嘧啶合成路线 （共 3 条）
反应条件
acetic acid; 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in acetonitrile T=70°C; 14 h;
参考文献
Hu, Weidong; Wang, Ping'An; Song, Chuanjun; Pan, Zhenliang; Wang, Qiang; Guo, Xiaohe; Yu, Xuejun; Shen, Zhenhua; Wang, Shuyang; Chang, Junbiao
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 24 p. 7297 - 7298
反应条件
1: With n-butyllithium in tetrahydrofuran T=-78°C; 0.5 h; 2: With N-fluoro-N-(phenylsulfonyl)benzene-sulfonamide in tetrahydrofuran T=-78°C; 0.25 h;
参考文献
MICROLOGIX BIOTECH INC.
Patent: WO2004/11478 A2, 2004 ;
Location in patent: Page 27 ;
反应条件
1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo-[2.2.2]octane bis(tetrafluoroborate) in acetonitrile T=20°C; 7 h;
参考文献
WO2006/65335 A2, ;
Page/Page column 21; 22 ;
WO 2006/065335 A2
