5-(1-萘)噻吩-2-羧酸合成路线 （共 2 条）
反应条件
1: With potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethanol; water
Suzuki Coupling; 4 h; Heating / reflux;
2: With hydrogenchloride in water
参考文献
THE J. DAVID GLADSTONE INSTITUTES; ITHACA COLLEGE
Patent: WO2008/101186 A1, 2008 ;
Location in patent: Page/Page column 83; sheet 9/9 ;
WO 2008/101186 A1
反应条件
ethylaluminum dichloride in hexane; toluene
T=100°C; P=22502.3 Torr; 3 h; AutoclaveInert atmosphere; regioselective reaction;
参考文献
Nemoto, Koji; Onozawa, Satoru; Konno, Megumi; Morohashi, Naoya; Hattori, Tetsutaro
Bulletin of the Chemical Society of Japan, 2012 , vol. 85, # 3 p. 369 - 371
