1-(2-羟基苯基)哌嗪二氢溴酸合成路线 （共 5 条）
反应条件
hydrogen bromide 90 h; Heating;
参考文献
Martin; Elgin Jr.; Mathiasen; Davis; Kesslick; Baldy; Shank; DiStefano; Fedde; Scott
Journal of Medicinal Chemistry, 1989 , vol. 32, # 5 p. 1052 - 1056
反应条件
1: K2CO3 / bis-(2-methoxy-ethyl) ether / 48 h / Heating 2: 48percent HBr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 5 p. 630 - 634
反应条件
water; hydrogen bromide
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 6, p. 211,218
反应条件
triethylamine in 1,4-dioxane; water
参考文献
Biovitrum AB
Patent: US6465467 B1, 2002 ;
US 6465467 B1
反应条件
potassium carbonate in water
参考文献
JANSSEN PHARMACEUTICA, N.V.
Patent: WO2006/50048 A1, 2006 ;
Location in patent: Page/Page column 72-74 ;
WO 2006/050048 A1
