N,N-二乙基苯甲酰胺-4-羧醛合成路线 （共 14 条）
反应条件
1: With 2-fluoro-pyridine; trifluoromethylsulfonic anhydride in dichloromethane
T=-78 - 0°C; Inert atmosphere;
2: With triethylsilane in dichloromethane
T=0 - 25°C; Inert atmosphere;
3: With citric acid in tetrahydrofuran; dichloromethane; water
T=45°C; 2 h; chemoselective reaction;
参考文献
Pelletier, Guillaume; Bechara, William S.; Charette, Andre B.
Journal of the American Chemical Society, 2010 , vol. 132, # 37 p. 12817 - 12819
反应条件
triethylamine in tetrahydrofuran; n-heptane; ethyl acetate
参考文献
Brown, William; Walpole, Christopher; Plobeck, Niklas
Patent: US2003/119845 A1, 2003 ;
反应条件
1: N,N-diethylbenzamide-4-carboxaldehyde; (-)-(2R,5S)-1-allyl-2,5-dimethylpiperazine With 1,2,3-Benzotriazole in toluene
2 - 3 h; Heating / reflux;
2: (3-methoxyphenyl)-magnesium bromide T=0 - 20°C; 1.5 h;
3: With water; ammonium chloride
参考文献
MOUNT COOK BIOSCIENCES, INC.
Patent: WO2007/27987 A2, 2007 ;
Location in patent: Page/Page column 23-24 ;
WO 2007/027987 A2
反应条件
1: benzene / Heating
2: tetrahydrofuran / 3 h / 20 °C
View Scheme
参考文献
Furness; Zhang; Coop; Jacobson; Rothman; Dersch; Xu; Porreca; Rice
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3193 - 3196
