4-(三氟甲基)苯甲酸乙酯合成路线 （共 49 条）
反应条件
pyridine; copper(l) iodide in 1-methyl-pyrrolidin-2-one T=200 - 205°C; Inert atmosphere;
参考文献
Chen, Mao; Buchwald, Stephen L.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 44 p. 11628 - 11631
Angew. Chem., 2013 , vol. 125, # 44 p. 11842 - 11845,4
反应条件
triethylamine tris(hydrogen fluoride) in N,N-dimethyl-formamide T=23 - 50°C; 42 h; Inert atmosphere; TemperatureTime;
参考文献
Lishchynskyi, Anton; Novikov, Maxim A.; Martin, Eddy; Escudero-Adan, Eduardo C.; Novak, Petr; Grushin, Vladimir V.
Journal of Organic Chemistry, 2013 , vol. 78, # 22 p. 11126 - 11146
反应条件
1: Zn(CF3)Br*2DMF With copper(I) bromide in N,N-dimethyl-formamide T=20°C; 3 h; 2: 4-iodobenzoic acid ethyl ester in N,N-dimethyl-formamide T=85 - 90°C; 8 h;
参考文献
Kremlev, Mikhail M.; Tyrra, Wieland; Mushta, Aleksej I.; Naumann, Dieter; Yagupolskii, Yurii L.
Journal of Fluorine Chemistry, 2010 , vol. 131, # 2 p. 212 - 216
反应条件
1: C15H23N3O2 With methyl iodide T=110°C; Inert atmosphere; 2: (trifluoromethyl)-trimethylsilane With potassium fluoride; copper(l) iodide in 1-methyl-pyrrolidin-2-one T=60°C; 16 h; Inert atmosphere;
参考文献
Hafner, Andreas; Braese, Stefan
Advanced Synthesis and Catalysis, 2013 , vol. 355, # 5 p. 996 - 1000
参考文献
Dust, Julian M.; Arnold, Donald R.
Journal of the American Chemical Society, 1983 , vol. 105, # 5 p. 1221 - 1227
反应条件
oxygen; triethylamine tris(hydrogen fluoride) in N,N-dimethyl-formamide T=25°C; 0.5 h;
参考文献
Novak, Petr; Lishchynskyi, Anton; Grushin, Vladimir V.
Angewandte Chemie - International Edition, 2012 , vol. 51, # 31 p. 7767 - 7770
反应条件
copper(l) iodide in N,N-dimethyl-formamide T=120°C; 8 h;
参考文献
Chen, Qing-Yun; Duan, Jian-Xing
Journal of the Chemical Society, Chemical Communications, 1993 , # 18 p. 1389 - 1391
反应条件
potassium fluoride; copper(l) iodide; 1,10-phenanthroline in 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide T=20 - 60°C; Inert atmosphere;
参考文献
Oishi, Masahiro; Kondo, Hideaki; Amii, Hideki
Chemical Communications, 2009 , # 14 p. 1909 - 1911
反应条件
sodium ethanolate; copper 16 h; Reflux;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 17 p. 5218 - 5227
参考文献
Journal of the American Chemical Society, , vol. 71, p. 1767,1768, 3482, 3485
