4-(三氟甲基)苯甲酸乙酯合成路线 （共 49 条）
反应条件
potassium fluoride; copper(l) iodide in N,N-dimethyl-formamide T=80°C; 24 h;
参考文献
Tetrahedron Letters, , vol. 32, # 1 p. 91 - 94
反应条件
copper; silver(l) oxide in N,N-dimethyl-formamide T=130°C; 15 h; Inert atmosphere;
参考文献
Li, Yaming; Chen, Tao; Wang, Huifeng; Zhang, Rong; Jin, Kun; Wang, Xiuna; Duan, Chunying
Synlett, 2011 , # 12 p. 1713 - 1716
反应条件
in N,N-dimethyl-formamide T=50°C; 18 h; Inert atmosphere; Product distribution / selectivity;
参考文献
THE BOARD OF TRUSTESS OF THE UNIVERSITY OF ILLINOIS; HARTWIG, John, F.; MORIMOTO, Hiroyuki; FIER, Patrick
Patent: WO2012/24564 A1, 2012 ;
Location in patent: Page/Page column 7; 31 ;
反应条件
sodium chloride in water T=-78 - 20°C; 3 h; Inert atmosphereSchlenk technique;
参考文献
Wang, Xi; Xu, Yan; Mo, Fanyang; Ji, Guojing; Qiu, Di; Feng, Jiajie; Ye, Yuxuan; Zhang, Songnan; Zhang, Yan; Wang, Jianbo
Journal of the American Chemical Society, 2013 , vol. 135, # 28 p. 10330 - 10333
反应条件
1: ethyl 4-aminobenzoate hydrochloride With tert.-butylnitrite in water T=0°C; 0.25 h; Inert atmosphereSchlenk technique; 2: trifluoromethylsilver T=-78 - 20°C; 4 h; Inert atmosphereSchlenk technique;
参考文献
Wang, Xi; Xu, Yan; Mo, Fanyang; Ji, Guojing; Qiu, Di; Feng, Jiajie; Ye, Yuxuan; Zhang, Songnan; Zhang, Yan; Wang, Jianbo
Journal of the American Chemical Society, 2013 , vol. 135, # 28 p. 10330 - 10333
反应条件
1: 4-amino-benzoic acid ethyl ester With hydrogenchloride in water T=0°C; 0.0833333 h; Inert atmosphereSchlenk technique; 2: With sodium nitrite T=0°C; 0.25 h; Inert atmosphereSchlenk technique; 3: trifluoromethylcopper(I) T=0 - 20°C; 4 h; Inert atmosphereSchlenk technique;
参考文献
Wang, Xi; Xu, Yan; Mo, Fanyang; Ji, Guojing; Qiu, Di; Feng, Jiajie; Ye, Yuxuan; Zhang, Songnan; Zhang, Yan; Wang, Jianbo
Journal of the American Chemical Society, 2013 , vol. 135, # 28 p. 10330 - 10333
反应条件
iodine T=100°C; 72 h;
参考文献
Schlosser, Manfred; Keller, Holger
Liebigs Annalen, 1995 , # 9 p. 1587 - 1590
反应条件
1: 4-amino-benzoic acid ethyl ester With hydrogenchloride in water T=0°C; 0.0833333 h; Inert atmosphereSchlenk technique; 2: With tert.-butylnitrite T=0°C; 0.25 h; Inert atmosphereSchlenk technique; 3: 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; trifluoromethylsilver T=-78 - 20°C; 4 h; Inert atmosphereSchlenk technique;
参考文献
Journal of the American Chemical Society, , vol. 135, # 28 p. 10330 - 10333
反应条件
18-crown-6 ether; potassium carbonate in tetrahydrofuran 21 h; Inert atmosphereReflux;
参考文献
European Journal of Organic Chemistry, , # 26 p. 5886 - 5892
反应条件
pyridine; copper(l) iodide in 1-methyl-pyrrolidin-2-one T=200°C;
参考文献
Angewandte Chemie - International Edition, , vol. 52, # 44 p. 11628 - 11631
Angew. Chem., , vol. 125, # 44 p. 11842 - 11845,4
