5-硝基-噻吩-2-甲酸甲酯合成路线 （共 21 条）
反应条件
1: aqueous sulfuric acid 2: aqueous potassium permanganate solution; aq. NaOH solution 3: hydrogen chloride View Scheme
参考文献
Journal of the American Chemical Society, , vol. 74, p. 1356
反应条件
in dichloromethane T=0 - 20°C;
参考文献
ACS Medicinal Chemistry Letters, , vol. 2, # 9 p. 708 - 713
反应条件
sulfuric acid; nitric acid -20 deg C, then allowed to warm to 0 deg C over 0.5 h; Yields of byproduct given;
参考文献
Elliot, Richard, L.; O'Hanlon, Peter J.; Rogers, Norman H.
Tetrahedron, 1987 , vol. 43, # 14 p. 3295 - 3302
反应条件
nitric acid; acetic anhydride T=-10°C; 0.5 h; Yields of byproduct given;
参考文献
Cogolli, Pietro; Maiolo, Filippo; Testaferri, Lorenzo; Tiecco, Marcello; Tingoli, Marco
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1980 , p. 1331 - 1335
反应条件
1: hydrogen chloride 2: acetic acid anhydride; acetic acid; nitric acid View Scheme
参考文献
Annales Pharmaceutiques Francaises, , vol. 11, p. 509,518
参考文献
Gazzetta Chimica Italiana, , vol. 82, p. 773,801, 802
参考文献
Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), , p. 1331 - 1335
反应条件
T=45°C; Rate constant;
参考文献
Nippon Kagaku Zasshi, , vol. 77, p. 804,807
Chem.Abstr., , p. 9066
反应条件
hydrogen; palladium 10 on activated carbon in ethanol P=760.051 Torr;
参考文献
GLAXO GROUP LIMITED
Patent: WO2006/65788 A2, 2006 ;
Location in patent: Page/Page column 10 ;
WO 2006/065788 A2
参考文献
Centre International De Recherches Dermatologiques Galderma
Patent: US5709867 A1, 1998 ;
