5-溴-2,3-二氢-1,4-苯并二氧烷合成路线 （共 4 条）
反应条件
potassium fluoride in DMF (N,N-dimethyl-formamide) T=135°C; 3 h;
参考文献
Corvas International, Inc.
Patent: US6342504 B1, 2002 ;
Location in patent: Page column 123 ;
US 6342504 B1
反应条件
1: tri(o-tolyl)phosphine, bis(dibenzylideneacetone)palladium(O), sodium tert-butoxide / toluene / 100 °C 2: trifluoroacetic acid / CH2Cl2 / Ambient temperature View Scheme
参考文献
Kerrigan, Frank; Martin, Claire; Thomas, Gerard H.
Tetrahedron Letters, 1998 , vol. 39, # 15 p. 2219 - 2222
反应条件
1: With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: With sulfur dioxide in tetrahydrofuran; hexane
0.166667 h;
3: With N-chloro-succinimide in acetic acid
T=-78 - 20°C; 1.25 h;
参考文献
Corvas International, Inc.
Patent: US6342504 B1, 2002 ;
Location in patent: Page column 123-124 ;
US 6342504 B1
反应条件
N-chloro-succinimide; n-butyllithium in tetrahydrofuran; hexane; dichloromethane; acetic acid
参考文献
E. I. Du Pont de Nemours and Company
Patent: US4502882 A1, 1985 ;
