4-(2-甲氧基苯基)哌啶合成路线 （共 11 条）
反应条件
1: 1.) LDA, 2.) PhN(SO2CF3)2, 3.) Pd(PPh3)4, LiCl, aq. Na2CO3, 4.) H2 / 4.) Pd/C 2: HCl / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 14 p. 1851 - 1856
反应条件
palladium monocarbide in ethanol
参考文献
SSP Co., Ltd.
Patent: EP1325912 A1, 2003 ;
EP 1325912 A1
反应条件
palladium 10 on activated carbon; hydrogen in ethanol T=20°C; 5 h;
参考文献
Choi, Yeon Jae; Seo, Jae Hong; Shin, Kye Jung
Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 880 - 883
反应条件
hydrogenchloride in methanol Yield given;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 14 p. 1851 - 1856
反应条件
1: 1.) LDA, 2.) PhN(SO2CF3)2, 3.) Pd(PPh3)4, LiCl, aq. Na2CO3, 4.) H2 / 4.) Pd/C 2: HCl / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 8, # 14 p. 1851 - 1856
反应条件
1: hydrogen; palladium hydroxide on carbon / ethanol / 80 °C 2: hydrogenchloride / methanol; isopropyl alcohol / 1.5 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 20 p. 8685 - 8699,15
Journal of Medicinal Chemistry, , vol. 55, # 20 p. 8685 - 8699
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 1.5 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 11 p. 1998 - 2008
反应条件
1: 1.) urea, 2.) ethanol / 1.) 160 deg C - 180 deg C, 2 h, 2.) reflux, 10 min 2: LiAlH4 / tetrahydrofuran / 1.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 11 p. 1998 - 2008
反应条件
1: 1.) piperidine, 2.) KOH / 1.) 0 deg C to RT, 3 days, 2.) water, 80 deg C - 85 deg C, 2 h 2: 1.) urea, 2.) ethanol / 1.) 160 deg C - 180 deg C, 2 h, 2.) reflux, 10 min 3: LiAlH4 / tetrahydrofuran / 1.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 38, # 11 p. 1998 - 2008
反应条件
1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C / |Reflux 2: palladium 10 on activated carbon; hydrogen / ethanol / 5 h / 20 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 24, # 3 p. 880 - 883
