(S)-5-甲氧基-1,2,3,4-四氢-N-(苯甲基)-2-萘胺合成路线 (共 7 条)
反应条件
1: 99 percent / K2CO3 / butan-2-one / 30 h / 90 °C 2: 84 percent / H2, AcOH / 10percent Pd/C / ethanol / Ambient temperature View Scheme
参考文献
Seiler, Max P.; Stoll, Andre P.; Closse, Annemarie; Frick, Willy; Jaton, Annelise; Vigouret, Jean-Marie
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 912 - 917
反应条件
Yield given. Multistep reaction;
参考文献
Bakthavachalam, Venkatesalu; Baindur, Nandkishore; Madras, Bertha K.; Neumeyer, John L.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3235 - 3241
反应条件
potassium carbonate in water; ethyl acetate
参考文献
Laboratorios del Dr. Esteve S.A.
Patent: EP1956006 A1, 2008 ;
Location in patent: Page/Page column 27 ;
EP 1956006 A1
反应条件
1: 1.) p-TsOH, 2.) H2 / 2.) PtO2 / 1.) toluene, reflux, 2 h, 2.) EtOH, 32 psi, 1 h
View Scheme
参考文献
Bakthavachalam, Venkatesalu; Baindur, Nandkishore; Madras, Bertha K.; Neumeyer, John L.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3235 - 3241
反应条件
1: 1.) p-TsOH, 2.) H2 / 2.) PtO2 / 1.) toluene, reflux, 2 h, 2.) EtOH, 32 psi, 1 h
View Scheme
参考文献
Bakthavachalam, Venkatesalu; Baindur, Nandkishore; Madras, Bertha K.; Neumeyer, John L.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3235 - 3241
参考文献
Bakthavachalam, Venkatesalu; Baindur, Nandkishore; Madras, Bertha K.; Neumeyer, John L.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3235 - 3241
反应条件
1: 99 percent / K2CO3 / butan-2-one / 30 h / 90 °C
2: 84 percent / H2, AcOH / 10percent Pd/C / ethanol / Ambient temperature
3: 61 percent / 48percent HBr / 15 h / 130 °C
View Scheme
参考文献
Seiler, Max P.; Stoll, Andre P.; Closse, Annemarie; Frick, Willy; Jaton, Annelise; Vigouret, Jean-Marie
Journal of Medicinal Chemistry, 1986 , vol. 29, # 6 p. 912 - 917