1-甲基-对甲苯磺酰甲基异腈合成路线 （共 4 条）
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in dichloromethane; water T=0°C; 3 h;
参考文献
Kissei Pharmaceutical Co., Ltd.
Patent: EP1932833 A1, 2008 ;
Location in patent: Page/Page column 33; 35 ;
EP 1932833 A1
反应条件
1: With trichlorophosphate in tetrahydrofuran 0.5 h; 2: With triethylamine in tetrahydrofuran T=0°C; 0.5 h;
参考文献
US2008/51395 A1, ;
Page/Page column 109 ;
US 20080051395 A1
反应条件
sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride in dichloromethane; water T=0°C; 24 h;
参考文献
Baeza, Alejandro; Mendiola, Javier; Burgos, Carolina; Alvarez-Builla, Julio; Vaquero, Juan J.
Journal of Organic Chemistry, 2005 , vol. 70, # 12 p. 4879 - 4882
反应条件
sodium hydride in diethyl ether; dimethyl sulfoxide; mineral oil
T=20°C; 2 h;
参考文献
MENEAR, Keith Allan; Javaid, Muhammad Hashim; Gomez, Sylvie; Hummersone, Marc Geoffrey; Lence, Carlos Fenandez; Martin, Niall Morrison Barr; Rudge, David Alan; Roberts, Craig Anthony; Blades, Kevin
Patent: US2009/192156 A1, 2009 ;
Location in patent: Page/Page column 43-44 ;
