2,3-二甲基-4-羟基苯甲醛合成路线 （共 8 条）
反应条件
boron tribromide in dichloromethane
T=-78 - 20°C; 48 h;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2005/2574 A1, 2005 ;
Location in patent: Page 48-49 ;
反应条件
calcium hydroxide powder; sodium carbonate in water
T=85°C; Reimer-Tiemann reaction; 2 h;
参考文献
Winn; Kester; Von Geldern; Leitza; Devries; Dickinson; Mussatto; Okasinski; Reilly; Liu; Huth; Jae; Freeman; Pei; Xin; Lynch
Journal of Medicinal Chemistry, 2001 , vol. 44, # 25 p. 4393 - 4403
反应条件
hydrogenchloride; aluminium trichloride; benzene
anfangs unter Kuehlung, schliesslich bei 40grad; man giesst das Reaktionsgemisch auf Eis, saeuert mit Salzsaeure an und destilliert mit Wasserdampf;
参考文献
Gattermann
Justus Liebigs Annalen der Chemie, 1907 , vol. 357, p. 373
反应条件
hydrogenchloride; aluminium trichloride; hydrogen cyanide
参考文献
v. Auwers; Mauss
Chemische Berichte, 1928 , vol. 61, p. 1502
反应条件
1: 2,3-Dimethyl-4-hydroxybenzaldehyde With potassium carbonate in DMF (N,N-dimethyl-formamide)
T=20°C; 0.166667 h;
2: propyl bromide in DMF (N,N-dimethyl-formamide)
T=50°C;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2005/2574 A1, 2005 ;
Location in patent: Page 49 ;
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
T=20°C;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2005/2574 A1, 2005 ;
Location in patent: Page 53 ;
反应条件
pyridine; trifluoromethanesulfonic acid anhydride in dichloromethane
参考文献
FUJISAWA PHARMACEUTICAL CO., LTD.
Patent: US2004/6143 A1, 2004 ;
US 20040006143 A1
反应条件
pyridine
T=25°C; 1 h;
参考文献
Winn; Kester; Von Geldern; Leitza; Devries; Dickinson; Mussatto; Okasinski; Reilly; Liu; Huth; Jae; Freeman; Pei; Xin; Lynch
Journal of Medicinal Chemistry, 2001 , vol. 44, # 25 p. 4393 - 4403
