1: With hydrogen bromide; NH4Br; copper(I) bromide; copper 2: With lithium aluminium tetrahydride in ethylene glycol dimethyl ether

1: methyl propargyl bromide With aluminium; mercury dichloride in tetrahydrofuran; diethyl ether 2: formaldehyd in tetrahydrofuran; diethyl ether T=55°C; Further stages.;

pyridinium poly(hydrogen fluoride) in acetonitrile 14 h; Inert atmosphere;

(i) nBuLi, (ii) /BRN= 1209228/, (iii) KNH2, liq. NH3; Multistep reaction;