5,6-二氢-4H-吡咯并[3,2,1-ij]喹啉合成路线 （共 21 条）
反应条件
quinoline; copper (II) chromite T=185°C; 3 h;
参考文献
Van Wijngaarden; Hamminga; Van Hes; Standaar; Tipker; Tulp; Mol; Olivier; De Jonge
Journal of Medicinal Chemistry, 1993 , vol. 36, # 23 p. 3693 - 3699
反应条件
1: With quinoline; copper T=238°C; 3 h; 2: With hydrogenchloride in water 3: With sodium hydroxide in water
参考文献
Shi, Zhuangzhi; Zhang, Chun; Li, Si; Pan, Delin; Ding, Shengtao; et al.
Angewandte Chemie, International Edition, 2009 , vol. 48, p. 4572 - 4576
Angewandte Chemie, 2009 , vol. 121, p. 4642 - 4646
反应条件
palladium 10 on activated carbon; zinc in water T=150°C; 24 h; Autoclave;
参考文献
Organic and Biomolecular Chemistry, , vol. 10, # 9 p. 1826 - 1833
反应条件
quinoline; copper oxide-chromium oxide; hydrogen T=190°C;
参考文献
Journal of the American Chemical Society, , vol. 60, p. 2414
反应条件
1: tetrahydrofuran / 24 h / Ambient temperature 2: MgCl2 / 2-methoxy-ethanol; tetrahydrofuran / 6 h / 125 °C 3: 94 percent / aq. NaOH / ethanol / 2 h / Heating 4: 93 percent / copper chromite, quinoline / 3 h / 185 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 23 p. 3693 - 3699
反应条件
palladium 10 on activated carbon; zinc in water T=150°C; 24 h; Autoclave;
参考文献
Abarca, Belen; Adam, Rosa; Ballesteros, Rafael
Organic and Biomolecular Chemistry, 2012 , vol. 10, # 9 p. 1826 - 1833
反应条件
1: 94 percent / aq. NaOH / ethanol / 2 h / Heating 2: 93 percent / copper chromite, quinoline / 3 h / 185 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 23 p. 3693 - 3699
反应条件
1: MgCl2 / 2-methoxy-ethanol; tetrahydrofuran / 6 h / 125 °C 2: 94 percent / aq. NaOH / ethanol / 2 h / Heating 3: 93 percent / copper chromite, quinoline / 3 h / 185 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 23 p. 3693 - 3699
反应条件
1: 94.8 percent / CF3COOH / acetonitrile / 4 h 2: 88.6 percent / 1.8 N aq. sodium hypochlorite, 2.6 N aq. NaOH / ethanol / 1 h / 70 °C 3: 93 percent / 66percent aq. AcOH / 1 h / Ambient temperature 4: 1.) 10percent aq. H2SO4, 2.) Ac2O, pyridine / 1.) ethanol, 3.5 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 41, # 5 p. 816 - 821
反应条件
1: 88.6 percent / 1.8 N aq. sodium hypochlorite, 2.6 N aq. NaOH / ethanol / 1 h / 70 °C 2: 93 percent / 66percent aq. AcOH / 1 h / Ambient temperature 3: 1.) 10percent aq. H2SO4, 2.) Ac2O, pyridine / 1.) ethanol, 3.5 h View Scheme
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 41, # 5 p. 816 - 821
