3-(4-异丙苯基)丙酸合成路线 （共 19 条）
反应条件
1: sodium; alcohol / man verseift den Diaethylester mit Natronlauge 2: 160 °C View Scheme
参考文献
Chemische Berichte, , vol. 22, p. 2279
Chemische Berichte, , vol. 23, p. 3086
反应条件
1: TiCl4, BF3-Et2O / -30 °C 2: Ag2O View Scheme
参考文献
Bulletin de la Societe Chimique de France, , p. 1194 - 1198
参考文献
Helvetica Chimica Acta, , vol. 5, p. 934
参考文献
Chemische Berichte, , vol. 22, p. 2279
Chemische Berichte, , vol. 23, p. 3086
参考文献
Widman
Chemische Berichte, 1889 , vol. 22, p. 2279
Chemische Berichte, 1890 , vol. 23, p. 3086
参考文献
Widman
Chemische Berichte, 1889 , vol. 22, p. 2279
Chemische Berichte, 1890 , vol. 23, p. 3086
反应条件
1: polyphosphoric acid / 1 h / 80 °C 2: KOt-Bu / diethyl ether; CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Cordi; Lacoste; Descombes; Courchay; Vanhoutte; Laubie; Verbeuren
Journal of Medicinal Chemistry, 1995 , vol. 38, # 20 p. 4056 - 4069
反应条件
1: diluted nitric acid
2: concentrated sulfuric acid; fuming nitric acid
3: ferrosulfate; ammonia
View Scheme
参考文献
Widman
Chemische Berichte, 1889 , vol. 22, p. 2279
Chemische Berichte, 1890 , vol. 23, p. 3086
反应条件
1: 3-(4-Isopropylphenyl)propionic acid With 1,1'-carbonyldiimidazole in dichloromethane
T=5°C; 1 h;
2: O,N-dimethyl-hydroxylamine hydrochloride in dichloromethane
T=5 - 20°C;
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2007/436 A1, 2007 ;
Location in patent: Page/Page column 38-39 ;
