Boc-3-(2-萘基)-L-丙氨酸合成路线 （共 15 条）
反应条件
alcalase CLEAreg;; 1,8-diazabicyclo[5.4.0]undec-7-ene in tert-butyl alcohol T=37°C; 696 h; Resolution of racemateEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
D'Arrigo, Paola; Cerioli, Lorenzo; Fiorati, Andrea; Servi, Stefano; Viani, Fiorenza; Tessaro, Davide
Tetrahedron Asymmetry, 2012 , vol. 23, # 13 p. 938 - 944
反应条件
triethylamine in 1,4-dioxane; water
参考文献
James Black Foundation Limited
Patent: US5486597 A1, 1996 ;
反应条件
sodium hydroxide in 1,4-dioxane pH 10;
参考文献
Rodriguez; Bernad; Galas; Lignon; Laur; Aumelas; Martinez
European Journal of Medicinal Chemistry, 1991 , vol. 26, # 3 p. 245 - 253
反应条件
hydrogenchloride; N-ethyl-N,N-diisopropylamine in ethyl acetate; N,N-dimethyl-formamide
反应条件
1: 80 percent / 1 M NaOH / aq. ethanol / 6 h / Ambient temperature 2: 97 percent / 0.17 h / 160 °C 3: 88 percent 4: 92 percent / 6 N aq. HCl / 2 h / Heating 5: 93 percent / 0.5 N aq. NaOH / dioxane / pH 10 View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 26, # 3 p. 245 - 253
反应条件
1: 92 percent / 6 N aq. HCl / 2 h / Heating 2: 93 percent / 0.5 N aq. NaOH / dioxane / pH 10 View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 26, # 3 p. 245 - 253
反应条件
1: 97 percent / 0.17 h / 160 °C 2: 88 percent 3: 92 percent / 6 N aq. HCl / 2 h / Heating 4: 93 percent / 0.5 N aq. NaOH / dioxane / pH 10 View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 26, # 3 p. 245 - 253
反应条件
1: 88 percent 2: 92 percent / 6 N aq. HCl / 2 h / Heating 3: 93 percent / 0.5 N aq. NaOH / dioxane / pH 10 View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 26, # 3 p. 245 - 253
反应条件
1: 92 percent / EtONa / ethanol / 6 h / Heating 2: 80 percent / 1 M NaOH / aq. ethanol / 6 h / Ambient temperature 3: 97 percent / 0.17 h / 160 °C 4: 88 percent 5: 92 percent / 6 N aq. HCl / 2 h / Heating 6: 93 percent / 0.5 N aq. NaOH / dioxane / pH 10 View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 26, # 3 p. 245 - 253
反应条件
1: 1,8-diazabicyclo[5.4.0]undec-7-ene / isopropyl alcohol / 40 °C 2: alcalase CLEAreg;; 1,8-diazabicyclo[5.4.0]undec-7-ene / #tert!-butyl alcohol / 696 h / 37 °C / Resolution of racemate; Enzymatic reaction View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 23, # 13 p. 938 - 944
