(S)-2-N-Cbz-3-N-Boc-丙酸甲酯合成路线

参考文献

ICOS CORPORATION
Patent: WO2005/16883 A2, 2005 ;
Location in patent: Page/Page column 294-295 ;

参考文献

Xue, Chu-Biao; Roderick, John; Jackson, Sharon; Rafalski, Maria; Rockwell, Arlene; Mousa, Shaker; Olson, Richard E.; DeGrado, William F.
Bioorganic and Medicinal Chemistry, 1997 , vol. 5, # 4 p. 693 - 705

186581-53-3重氮甲烷+

16947-84-52-(N-Cbz)-3-(N-Boc)-2,3-二氨基丙酸

58457-98-0(S)-2-N-Cbz-3-N-Boc-丙酸甲酯

参考文献

Webber, Stephen E.; Okano, Koji; Little, Thomas L.; Reich, Siegfried H.; Xin, Yue; Fuhrman, Sheila A.; Matthews, David A.; Love, Robert A.; Hendrickson, Thomas F.; Patick, Amy K.; Meador III, James W.; Ferre, Rose Ann; Brown, Edward L.; Ford, Clifford E.; Binford, Susan L.; Worland, Stephen T.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 15 p. 2786 - 2805

16947-84-52-(N-Cbz)-3-(N-Boc)-2,3-二氨基丙酸+

74-88-4甲基碘

58457-98-0(S)-2-N-Cbz-3-N-Boc-丙酸甲酯

参考文献

US2012/178773 A1, ;

Page/Page column 25-26 ;

35761-26-33-氨基-N-Cbz-L-丙氨酸

58457-98-0(S)-2-N-Cbz-3-N-Boc-丙酸甲酯

参考文献

Journal of Medicinal Chemistry, , vol. 42, # 13 p. 2409 - 2421

24424-99-5二碳酸二叔丁酯+

75760-11-1

58457-98-0(S)-2-N-Cbz-3-N-Boc-丙酸甲酯