(S)-2-N-Cbz-3-N-Boc-丙酸甲酯合成路线 （共 22 条）
反应条件
pyridine in acetonitrile 5 h; Ambient temperature;
参考文献
Egbertson; Homnick; Hartman
Synthetic Communications, 1993 , vol. 23, # 5 p. 703 - 709
反应条件
sodium methylate in methanol T=-10°C; 1 h;
参考文献
Synthesis, , # 7 p. 542 - 544
反应条件
1: 88.4 percent / 1 N aq. NaoH / dioxane / 48 h / 45 °C 2: Na, NH3(liq.) / 0.17 h / -50 °C 3: 61 percent / 4 N aq. NaOH / 2 h / 25 °C / pH 10-10.5 4: 79.5 percent / diethyl ether View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 5 p. 567 - 572
反应条件
1: Na, NH3(liq.) / 0.17 h / -50 °C 2: 61 percent / 4 N aq. NaOH / 2 h / 25 °C / pH 10-10.5 3: 79.5 percent / diethyl ether View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 5 p. 567 - 572
反应条件
1: 61 percent / 4 N aq. NaOH / 2 h / 25 °C / pH 10-10.5 2: 79.5 percent / diethyl ether View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 5 p. 567 - 572
反应条件
1: diphenyl phosphoroazidate, Et3N / 2-methyl-propan-2-ol / 2 h / 35 °C 2: 35 °C 3: NaOMe / methanol / 1 h / -10 °C View Scheme
参考文献
Synthesis, , # 7 p. 542 - 544
反应条件
1: sodium periodate; ruthenium trichloride; sodium hydrogencarbonate / tetrachloromethane; water; acetonitrile / 0.17 h / 0 °C / Inert atmosphere 2: diethyl ether; dichloromethane; benzene / 3 h / 0 - 20 °C / Inert atmosphere 3: sodium tetrahydroborate; nickel dichloride / methanol / 0.42 h / -5 °C / Inert atmosphere 4: 4-(N,N-dimethlyamino)pyridine / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere View Scheme
参考文献
Helvetica Chimica Acta, , vol. 94, # 8 p. 1543 - 1550
反应条件
hydrogenchloride in 1,4-dioxane T=20°C; 1 h;
参考文献
SUNESIS PHARMACEUTICALS, INC.
Patent: WO2005/44817 A1, 2005 ;
Location in patent: Page/Page column 134 ;
反应条件
hydrogen; palladium on activated charcoal in methanol 24 h;
参考文献
Journal of Medicinal Chemistry, , vol. 24, # 5 p. 567 - 572
反应条件
hydrogenchloride in ethyl acetate T=0°C; 0.5 h;
参考文献
Egbertson; Homnick; Hartman
Synthetic Communications, 1993 , vol. 23, # 5 p. 703 - 709
