1,3-二(2-氰基-5-(三氟甲基)苯基)三氮烯合成路线 (共 3 条)
反应条件
potassium hydroxide in methanol
1.) heating, 1.5 h, 2.) 25 deg C, 15 h;
参考文献
Hill; Stanley; Karoglan Williams; Loev; Fowler; McCafferty; Macko; Berkoff; Ladd
Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 865 - 869
反应条件
sodium hydride
1.) ether, 2.) ether, 25 deg C, 2 h; Yield given. Multistep reaction;
参考文献
Hill; Stanley; Karoglan Williams; Loev; Fowler; McCafferty; Macko; Berkoff; Ladd
Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 865 - 869
反应条件
in diethyl ether
Ambient temperature;
参考文献
Hill; Stanley; Karoglan Williams; Loev; Fowler; McCafferty; Macko; Berkoff; Ladd
Journal of Medicinal Chemistry, 1983 , vol. 26, # 6 p. 865 - 869