拉凡醇; 5-甲基-2-(1-甲基乙烯基)-4-己烯-1-醇合成路线 （共 65 条）
反应条件
1: K2CO3 / tetrahydrofuran / 8 h / Ambient temperature 2: 1.) n-Bu2CuLi / 1.) THF, -30 deg C, 20 min, 2.) 30 min 3: 95 percent / LiAlH4 View Scheme
参考文献
Gazzetta Chimica Italiana, , vol. 120, # 3 p. 203 - 205
反应条件
1: 71 percent / K2CO3 / H2O / 72 h / Ambient temperature 3: 85 percent / sodium bis(trimethylsilyl)amide / tetrahydrofuran; toluene / 0.5 h / Heating 4: 96 percent / HCl, KF, MeOH / CH2Cl2 / 2 h / Ambient temperature 5: 59 percent / H2O2, NaHCO3, H2O / methanol; tetrahydrofuran / 12 h / Heating View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 17 p. 2701 - 2709
反应条件
1: 50 percent / Et3N, DMAP / CH2Cl2 / 0.5 h / Ambient temperature 2: 38 percent / diethyl ether; tetrahydrofuran / 9 h / Ambient temperature 4: 85 percent / sodium bis(trimethylsilyl)amide / tetrahydrofuran; toluene / 0.5 h / Heating 5: 96 percent / HCl, KF, MeOH / CH2Cl2 / 2 h / Ambient temperature 6: 59 percent / H2O2, NaHCO3, H2O / methanol; tetrahydrofuran / 12 h / Heating View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 17 p. 2701 - 2709
反应条件
1: 38 percent / diethyl ether; tetrahydrofuran / 9 h / Ambient temperature 3: 85 percent / sodium bis(trimethylsilyl)amide / tetrahydrofuran; toluene / 0.5 h / Heating 4: 96 percent / HCl, KF, MeOH / CH2Cl2 / 2 h / Ambient temperature 5: 59 percent / H2O2, NaHCO3, H2O / methanol; tetrahydrofuran / 12 h / Heating View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 17 p. 2701 - 2709
反应条件
1: 24 percent / PCl3, DMF, pyridine / tetrahydrofuran / 1 h / Ambient temperature 2: 67 percent / TBAF / tetrahydrofuran / 5 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 17 p. 2701 - 2709
反应条件
1: 70 percent / H2O2, H2O, KF, KHCO3 / tetrahydrofuran; methanol / 0.33 h / Ambient temperature 2: 69 percent / Et3N, DMAP / CH2Cl2 / 48 h / Ambient temperature 3: 24 percent / PCl3, DMF, pyridine / tetrahydrofuran / 1 h / Ambient temperature 4: 67 percent / TBAF / tetrahydrofuran / 5 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 17 p. 2701 - 2709
反应条件
1: 80 percent / HCl, MeOH / CH2Cl2 / 0.02 h / Ambient temperature 2: 70 percent / H2O2, H2O, KF, KHCO3 / tetrahydrofuran; methanol / 0.33 h / Ambient temperature 3: 69 percent / Et3N, DMAP / CH2Cl2 / 48 h / Ambient temperature 4: 24 percent / PCl3, DMF, pyridine / tetrahydrofuran / 1 h / Ambient temperature 5: 67 percent / TBAF / tetrahydrofuran / 5 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 17 p. 2701 - 2709
反应条件
1: 80 percent / diethyl ether; tetrahydrofuran / 24 h / Ambient temperature 2: 80 percent / HCl, MeOH / CH2Cl2 / 0.02 h / Ambient temperature 3: 70 percent / H2O2, H2O, KF, KHCO3 / tetrahydrofuran; methanol / 0.33 h / Ambient temperature 4: 69 percent / Et3N, DMAP / CH2Cl2 / 48 h / Ambient temperature 5: 24 percent / PCl3, DMF, pyridine / tetrahydrofuran / 1 h / Ambient temperature 6: 67 percent / TBAF / tetrahydrofuran / 5 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 17 p. 2701 - 2709
反应条件
1.1: lithium diisopropyl amide / n-heptane; tetrahydrofuran / 0.25 h / -78 °C / |Inert atmosphere 1.2: 1 h / -78 °C / |Inert atmosphere 2.1: lithium aluminium tetrahydride / diethyl ether / 1.33 h / 0 - 20 °C / |Inert atmosphere View Scheme
参考文献
Journal of Organic Chemistry, , vol. 79, # 6 p. 2564 - 2573
反应条件
Montmorillonite K 10 Ambient temperature;
参考文献
Tetrahedron, , vol. 55, # 9 p. 2591 - 2608
