N-(2-羟基-4-甲氧基苯基)乙酰胺合成路线 （共 6 条）
反应条件
1: 2-hydroxy-4-methoxynitrobenzene With hydrogen; palladium 10 on activated carbon in tetrahydrofuran
T=20°C;
2: acetic anhydride in tetrahydrofuran; water
T=60°C; 1 h;
参考文献
ASTRAZENECA AB
Patent: WO2004/5295 A1, 2004 ;
Location in patent: Page 72-73 ;
反应条件
in water
T=60°C; 1 h;
参考文献
ASTRAZENECA AB?
Patent: WO2005/49620 A1, 2005 ;
Location in patent: Page/Page column 37 ;
WO 2005/049620 A1
反应条件
trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene in chloroform
0.0833333 h; Heating;
参考文献
Itoh, Naoki; Sakamoto, Takeshi; Miyazawa, Etsuko; Kikugawa, Yasuo
Journal of Organic Chemistry, 2002 , vol. 67, # 21 p. 7424 - 7428
反应条件
chloroform; tris-(2-chloro-ethyl)-amine; sulfuric acid
参考文献
Palazzo; Mazzone
Annali di Chimica (Rome, Italy), 1958 , vol. 48, p. 1329,1332, 1333
参考文献
Lindemann; Koenitzer; Romanoff
Justus Liebigs Annalen der Chemie, 1927 , vol. 456, p. 308
参考文献
Lindemann; Koenitzer; Romanoff
Justus Liebigs Annalen der Chemie, 1927 , vol. 456, p. 308
