1-甲基-3-异丁基-4-氨基脲嘧啶合成路线 （共 7 条）
反应条件
sodium hydroxide; ethanol
参考文献
Journal of Organic Chemistry, , vol. 16, p. 1879,1881,1887
反应条件
sodium hydroxide; acetic anhydride 1.) 70 deg C, 2 h, 2.) from 20 to 70 deg C, 1 h; Multistep reaction;
参考文献
European Journal of Medicinal Chemistry, , vol. 25, # 8 p. 653 - 658
反应条件
acetic acid; sodium nitrite in water 2 h; Ambient temperature;
参考文献
Wells; Garst; Kramer
Journal of Medicinal Chemistry, 1981 , vol. 24, # 8 p. 954 - 958
反应条件
1: NaNO2, AcOH / H2O / 2 h / Ambient temperature 2: Na2S2O4, 25percent aq. NH4OH / 20 - 50 °C 3: 2.) 2.2 M aq. NaOH / 1.) reflux, 2 h, 2.) reflux, 45 min 4: K2CO3 / dimethylformamide / 20 - 80 °C View Scheme
参考文献
Merlos; Gomez; Vericat; Bartroli; Garcia-Rafanell; Forn
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 8 p. 653 - 658
反应条件
1: NaNO2, AcOH / H2O / 2 h / Ambient temperature 2: Na2S2O4, 25percent aq. NH4OH / 20 - 50 °C 3: 2.) 2.2 M aq. NaOH / 1.) reflux, 2 h, 2.) reflux, 45 min View Scheme
参考文献
Merlos; Gomez; Vericat; Bartroli; Garcia-Rafanell; Forn
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 8 p. 653 - 658
反应条件
1: 20percent HOAc, NaNO2 / H2O
2: H2 / PtO2 / methanol / 2585.7 Torr
View Scheme
参考文献
Merlos; Gomez; Vericat; Bartroli; Garcia-Rafanell; Forn
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 8 p. 653 - 658
反应条件
1: NaNO2, AcOH / H2O / 2 h / Ambient temperature
2: Na2S2O4, 25percent aq. NH4OH / 20 - 50 °C
3: 2.) 2.2 M aq. NaOH / 1.) reflux, 2 h, 2.) reflux, 45 min
View Scheme
参考文献
Merlos; Gomez; Vericat; Bartroli; Garcia-Rafanell; Forn
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 8 p. 653 - 658
