5-氨基-2-氯吡啶-4-羧酸合成路线 （共 8 条）
反应条件
trifluoroacetic acid in dichloromethane
参考文献
Warner-Lambert Company
Patent: US5654307 A1, 1997 ;
US 5654307 A
反应条件
1.1: n-BuLi; TMEDA / toluene / -60 - -15 °C 1.2: 65 percent / toluene 2.1: 85 percent / aq. NaOH View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 11 p. 1401 - 1405
反应条件
1.1: 83 percent / (PhO)2PON3; Et3N / Heating 2.1: n-BuLi; TMEDA / toluene / -60 - -15 °C 2.2: 65 percent / toluene 3.1: 85 percent / aq. NaOH View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 11 p. 1401 - 1405
反应条件
1: 89 percent / dioxane / 12 h / Heating 2: 57 percent / TMEDA, BuLi / diethyl ether; hexane / 1.) -10 deg C, 2 h, 2.) -78 deg C to 20 deg C 3: 87 percent / TFA / CH2Cl2 View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 18 p. 2221 - 2226
参考文献
Warner-Lambert Company
Patent: US5654307 A1, 1997 ;
US 5654307 A
参考文献
Rewcastle, Gordon W.; Denny, William A.; Winters, R. Thomas; Colbry, Norman L.; Showalter, H. D. Hollis
Journal of the Chemical Society - Perkin Transactions 1, 1996 , # 18 p. 2221 - 2226
反应条件
in 2-methoxy-ethanol 18 h; Heating / reflux; Product distribution / selectivity;
参考文献
WO2005/16926 A1, ;
Page/Page column 123-124 ;
WO 2005/016926 A1
反应条件
in methanol; diethyl ether; toluene T=20°C; 2 h;
参考文献
SUMITOMO CHEMICAL COMPANY, LIMITED
Patent: WO2008/130021 A2, 2008 ;
Location in patent: Page/Page column 406-407 ;
