2-氯-7-甲氧基-4-甲基-喹唑啉合成路线 （共 4 条）
反应条件
N-ethyl-N,N-diisopropylamine; trichlorophosphate in toluene
T=80°C; 6 h;
参考文献
H. LUNDBECK A/S; KEHLER, Jan; KILBURN, John Paul; NIELSEN, Jacob; PÜSCHL, Ask; LANGGÅRD, Morten; JESSING, Mikkel; MARIGO, Mauro
Patent: WO2013/50527 A1, 2013 ;
Location in patent: Page/Page column 48; 49; 50 ;
反应条件
1: boron trichloride; AlCl3, aluminium chloride / toluene / 24 h / -5 - 25 °C / |Reflux
2: 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / 6 h / 0 - 20 °C
3: ammonium acetate / dimethyl sulfoxide / 20 h / 20 °C
4: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 6 h / 80 °C
View Scheme
参考文献
H. LUNDBECK A/S; KEHLER, Jan; KILBURN, John Paul; NIELSEN, Jacob; PÜSCHL, Ask; LANGGÅRD, Morten; JESSING, Mikkel; MARIGO, Mauro
Patent: WO2013/50527 A1, 2013 ;
反应条件
1: 4-(N,N-dimethlyamino)pyridine / tetrahydrofuran / 6 h / 0 - 20 °C
2: ammonium acetate / dimethyl sulfoxide / 20 h / 20 °C
3: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 6 h / 80 °C
View Scheme
参考文献
H. LUNDBECK A/S; KEHLER, Jan; KILBURN, John Paul; NIELSEN, Jacob; PÜSCHL, Ask; LANGGÅRD, Morten; JESSING, Mikkel; MARIGO, Mauro
Patent: WO2013/50527 A1, 2013 ;
反应条件
1: ammonium acetate / dimethyl sulfoxide / 20 h / 20 °C
2: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 6 h / 80 °C
View Scheme
参考文献
H. LUNDBECK A/S; KEHLER, Jan; KILBURN, John Paul; NIELSEN, Jacob; PÜSCHL, Ask; LANGGÅRD, Morten; JESSING, Mikkel; MARIGO, Mauro
Patent: WO2013/50527 A1, 2013 ;
