Alpha,Alpha-二甲基苄胺合成路线 （共 46 条）
参考文献
Vaughan,W.R.; Carlson,R.D.
Journal of the American Chemical Society, 1962 , vol. 84, p. 769 - 774
反应条件
2-chloro-1-methyl-pyridinium iodide; triethylamine in dichloromethane
2 h; Heating;
参考文献
Sato, Kazuo; Honma, Toyokuni; Sugai, Soji
Agricultural and Biological Chemistry, 1985 , vol. 49, # 12 p. 3563 - 3568
反应条件
sodium hydrogencarbonate in dichloromethane; toluene
T=0°C; 3 h;
参考文献
ALI, Amjad; Lo, Michael Man-Chu; Whitehead, Brent; Shah, Shrenik K.; Yan, Lin; Henderson, Timothy J.; Guo, Zack Zhiqiang
Patent: US2012/232039 A1, 2012 ;
Location in patent: Page/Page column 13 ;
反应条件
N-ethyl-N,N-diisopropylamine in dichloromethane
0.166667 h;
参考文献
PHARMACOPEIA, INC.
Patent: WO2008/11392 A2, 2008 ;
Location in patent: Page/Page column 42 ;
WO 2008/011392 A2
反应条件
1: diethyl ether
2: alcohol; ammonia / 180 - 185 °C
View Scheme
参考文献
Brander
Recueil des Travaux Chimiques des Pays-Bas, 1918 , vol. 37, p. 83
反应条件
1: 95 percent / diethyl ether; hexane / 1.5 h / 20 °C
2: 90 percent / aq. NaOH; NaOCl / 20 °C
3: Thermolysis
View Scheme
参考文献
Engel; Pan; Ying; Alemany
Journal of the American Chemical Society, 2001 , vol. 123, # 16 p. 3706 - 3715
