反应条件
1: 3-t-butylphenol With sodium hydride in tetrahydrofuran; mineral oil
T=0°C;
2: ethyl alpha-chloroacetoacetate With sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide; mineral oil
T=-20 - 70°C;
3: With hydrazine in ethanol
T=20°C;
参考文献
Chen, Tian; Benmohamed, Radhia; Kim, Jinho; Smith, Karen; Amante, Daniel; Morimoto, Richard I.; Kirsch, Donald R.; Ferrante, Robert J.; Silverman, Richard B.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 1 p. 515 - 527
