3-(3-三氟甲基苯基)丙酸合成路线 （共 17 条）
反应条件
trifluorormethanesulfonic acid T=20 - 60°C; 3 h;
参考文献
Astellas Pharma Inc.
Patent: EP2042480 A1, 2009 ;
Location in patent: Page/Page column 13 ;
反应条件
1.1: thionyl chloride / 4 h / |Inert atmosphere; |Reflux 2.1: sodium tetrahydroborate / tetrahydrofuran / |Inert atmosphere; |Reflux 2.2: 9 h / 60 - 65 °C / |Inert atmosphere 3.1: hydrogen bromide / water / 15 h / 85 - 90 °C View Scheme
参考文献
Beilstein Journal of Organic Chemistry, , vol. 8, p. 1366 - 1373
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 15 h / 20 °C / Inert atmosphere 2: lithium aluminium tetrahydride / diethyl ether / 5 h / Reflux View Scheme
参考文献
Journal of Organic Chemistry, , vol. 76, # 7 p. 2187 - 2194
反应条件
1: 85 percent / LAH 2: 65 percent / (COCl)2/DMSO; Et3N View Scheme
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY , Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; RAJI REDDY, Rapolu; MUKUNDA REDDY, Jambula; VAMSI KRISHNA, Bandi
Patent: WO2012/7954 A1, 2012 ;
反应条件
1.1: MeOH
2.1: N-BuLi / tetrahydrofuran / 0 °C
2.2: 80 percent / tetrahydrofuran
3.1: NaHMDS / 1,2-dimethoxy-ethane
3.2: 50 percent / 1,2-dimethoxy-ethane
4.1: (S)-BINAL-H; LiAlH4 / tetrahydrofuran
5.1: K2CO3; MeOH
6.1: p-TSA / CH2Cl2
7.1: DIBAL-H / -78 °C
8.1: NaHMDS
9.1: aq. AcOH / tetrahydrofuran
View Scheme
参考文献
DeLong, Mitchell A.; Amburgey, Jack; Taylor, Cynthia; Wos, John A.; Soper, David L.; Wang, Yili; Hicks, Renee
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 14 p. 1519 - 1522
参考文献
May and Baker Limited
Patent: US4243683 A1, 1981 ;
反应条件
1: thionyl chloride
View Scheme
参考文献
Fieser et al.
Journal of the American Chemical Society, 1948 , vol. 70, p. 3177
