3-羟基-5-甲基苯甲酸合成路线 （共 27 条）
参考文献
ApSimon,J.W. et al.
Journal of the Chemical Society, 1965 , p. 4144 - 4156
反应条件
potassium carbonate in acetone Reflux;
参考文献
Karmakar, Raju; Pahari, Pallab; Mal, Dipakranjan
Tetrahedron Letters, 2009 , vol. 50, # 28 p. 4042 - 4045
反应条件
1: alkali 2: sulfuric acid View Scheme
参考文献
Meldrum
Journal of the Chemical Society, 1911 , vol. 99, p. 1718
反应条件
1: 86 percent / K2CO3 / acetone / 12 h / Heating 2: 90 percent / LiAlH4 / tetrahydrofuran / 1 h / Heating View Scheme
参考文献
De Frutos, Oscar; Echavarren, Antonio M.
Tetrahedron Letters, 1996 , vol. 37, # 49 p. 8953 - 8956
反应条件
1: 86 percent / K2CO3 / acetone / 12 h / Heating
2: 90 percent / LiAlH4 / tetrahydrofuran / 1 h / Heating
3: 85 percent / PCC / CH2Cl2 / 2 h / 23 °C
View Scheme
参考文献
De Frutos, Oscar; Echavarren, Antonio M.
Tetrahedron Letters, 1996 , vol. 37, # 49 p. 8953 - 8956
反应条件
1: 78 percent / 30percent aq. NaOH / 24 h / 100 °C
2: SOCl2 / 24 h / 25 °C
3: 100 percent / CH2Cl2 / 24 h / 25 °C
4: 86 percent / SOCl2 / 1 h / Ambient temperature
View Scheme
参考文献
Tamura, Yasumitsu; Fukata, Fumio; Sasho, Manabu; Tsugoshi, Teruhisa; Kita, Yasuyuki
Journal of Organic Chemistry, 1985 , vol. 50, # 13 p. 2273 - 2277
反应条件
1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C
2: methanol; sodium tetrahydroborate / 0.5 h / 20 °C
3: sodium hydroxide; water / ethanol / 1 h / |Reflux
View Scheme
参考文献
ADVINUS THERAPEUTICS LIMITED; KHARUL, Rajendra; BHUNIYA, Debnath; MOOKHTIAR, Kasim A.; SINGH, Umesh; HAZARE, Atul; PATIL, Satish; DATRANGE, Laxmikant; THAKKAR, Mahesh
Patent: WO2013/42139 A1, 2013 ;
