(E)-6,7-二氢喹啉-8(5H)-酮肟合成路线 （共 5 条）
反应条件
hydrogenchloride in acetone 16 h; Heating;
参考文献
McEachern; Yang; Chen; Skerlj; Bridger
Synthetic Communications, 2003 , vol. 33, # 20 p. 3497 - 3502
反应条件
hydrogen; palladium 10 on activated carbon in methanol P=2585.81 Torr; 18 h;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2006/20415 A1, 2006 ;
Location in patent: Page/Page column 112 ;
WO 2006/020415 A1
反应条件
hydroxylamine hydrochloride
Inert atmosphere;
参考文献
Wang, Deping; Zhang, Fuxing; Kuang, Daizhi; Yu, Jiangxi; Li, Junhua
Green Chemistry, 2012 , vol. 14, # 5 p. 1268 - 1271
反应条件
1: With n-butyllithium; lithium diisopropyl amide in hexane
T=-15°C;
2: With isopentyl nitrite in hexane
T=-15°C; 1 h;
参考文献
Crawford, Jason B.; Chen, Gang; Gauthier, David; Wilson, Trevor; Carpenter, Bryon; Baird, Ian R.; McEachern, Ernie; Kaller, Alan; Harwig, Curtis; Atsma, Bem; Skerlj, Renato T.; Bridger, Gary J.
Organic Process Research and Development, 2008 , vol. 12, # 5 p. 823 - 830
反应条件
1: With methanesulfonyl chloride; triethylamine in dichloromethane
1 h;
2: With potassium acetate in ethanol; water
T=110°C;
参考文献
BANYU PHARMACEUTICAL CO., LTD.
Patent: EP1726590 A1, 2006 ;
Location in patent: Page/Page column 86 ;
