2-甲基-2-丙基[(2S)-4-甲基-1-氧代-2-戊烷基]氨基甲酸酯合成路线 （共 5 条）
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 1 h;
参考文献
DeMattei; Leanna; Li; Nichols; Rasmussen; Morton
Journal of Organic Chemistry, 2001 , vol. 66, # 10 p. 3330 - 3337
反应条件
1: 10 percent / LDA; ZnBr2 / tetrahydrofuran / -78 - 20 °C 2: aq. NaOH / dioxane / 1.5 h / 20 °C View Scheme
参考文献
Sawyer, Tomi K.; Pals, Donald T.; Mao, Boryeu; Staples, Douglas J.; Vaux, Anne E. de; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 18 - 30
反应条件
multistep reaction, various reaction conditions; Product distribution;
参考文献
Wuts; Putt
Synthesis, 1989 , # 12 p. 951 - 953
反应条件
1.1: KHMDS / toluene / 0.25 h / 0 °C 1.2: 71 percent / toluene / 20 h / 20 °C 2.1: 85 percent / H2 / Pd/C / methanol / 20 °C 3.1: 62 percent / aq. NaIO4; RuCl3*3H2O / CCl4; acetonitrile / 24 h / 20 °C View Scheme
参考文献
Moutevelis-Minakakis, Panagiota; Sinanoglou, Charalambos; Loukas, Vassilios; Kokotos, George
Synthesis, 2005 , # 6 art. no. T08804ST, p. 933 - 938
反应条件
1: 1.) n-butyllithium / 11.) THF, hexane, -78 deg C, 1 h, 2.) THF, hexane, from -78 deg C to RT, 2 h
2: 1.) dicyclohexylborane, 2.) 30percent aq. H2O2, 10percent aq. NaOH / 1.) THF, from 0 deg C to RT, 1 h, 2.) THF, methanol, 0 deg C, 30 min.
3: 47 percent / HCl / dioxane / 1 h
View Scheme
参考文献
Johnson, Rodney L.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 10 p. 1351 - 1354
