N-(叔丁氧羰基)抑胃酶氨酸合成路线 （共 49 条）
反应条件
sodium hydroxide in acetone 0.0833333 h; Ambient temperature;
参考文献
Jouin, Patrick; Castro, Bertrand; Nisato, Dino
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1177 - 1182
反应条件
platinum(IV) oxide; oxygen in 1,4-dioxane; water T=55°C; 30 h;
参考文献
Sakaitani, Masahiro; Ohfune, Yasufumi
Tetrahedron Letters, 1987 , vol. 28, # 34 p. 3987 - 3990
反应条件
sodium hydroxide in 1,4-dioxane 1 h; Ambient temperaturepH 12.0-12.2;
参考文献
Rittle, Kenneth E.; Homnick, Carl F.; Ponticello, Gerald S.; Evans, Ben E.
Journal of Organic Chemistry, 1982 , vol. 47, # 15 p. 3016 - 3018
反应条件
1: With bis(cyclohexanyl)borane in tetrahydrofuran T=20°C; 2: With dihydrogen peroxide; sodium hydrogencarbonate T=20°C;
参考文献
Alemany, Carme; Bach, Jordi; Garcia, Jordi; Lopez, Marta; Rodriguez, Ana B.
Tetrahedron, 2000 , vol. 56, # 47 p. 9305 - 9312
反应条件
1: 10 percent / LDA; ZnBr2 / tetrahydrofuran / -78 - 20 °C 2: aq. NaOH / dioxane / 1.5 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 25 p. 7440 - 7449
反应条件
1: (3S,4S)-4-[(tert-butoxycarbonyl)amino]-3-hydroxy-6-methylheptanonitrile With hydrogenchloride in tetrahydrofuran T=120°C; 12 h; 2: di-tert-butyl dicarbonate With sodium hydrogencarbonate in methanol T=20°C; 2 h;
参考文献
Konno, Hiroyuki; Toshiro, Emi; Hinoda, Naoyuki
Synthesis, 2003 , # 14 p. 2161 - 2164
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 74 percent / tetrahydrofuran; hexane / 0.67 h / 0 °C 2.1: BH3*SMe2 / (S)-oxazaborolidine / tetrahydrofuran / 0 °C 3.1: dicyclohexylborane / tetrahydrofuran / 2 h / 0 - 20 °C 3.2: aq. H2O2 / aq. NaHCO3 / 20 °C 3.3: AcOH / 0 - 20 °C View Scheme
参考文献
Organic Letters, , vol. 1, # 11 p. 1831 - 1834
反应条件
acetic acid Ambient temperature;
参考文献
Yuste, Francisco; Diaz, Angel; Ortiz, Benjamin; Sanchez-Obregon, Ruben; Walls, Fernando; Garcia Ruano, Jose L.
Tetrahedron Asymmetry, 2003 , vol. 14, # 5 p. 549 - 554
反应条件
1.1: BH3*SMe2 / (S)-oxazaborolidine / tetrahydrofuran / 0 °C 2.1: dicyclohexylborane / tetrahydrofuran / 2 h / 0 - 20 °C 2.2: aq. H2O2 / aq. NaHCO3 / 20 °C 2.3: AcOH / 0 - 20 °C View Scheme
参考文献
Organic Letters, , vol. 1, # 11 p. 1831 - 1834
反应条件
1: triethylamine / tetrahydrofuran / 20 h / Ambient temperature 2: 60 percent / O2 / PtO2 / dioxane; H2O / 30 h / 55 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 28, # 34 p. 3987 - 3990
