N-(叔丁氧羰基)抑胃酶氨酸合成路线 （共 49 条）
反应条件
1: 92 percent / conc. HCl / 5 h / Ambient temperature 2: 84 percent / triethylamine / CH2Cl2 / 0.17 h / 0 °C 3: H2 / Pd, C (5percent) / toluene / 24 h / 15200 Torr / Ambient temperature 4: 1.) 48percent aq. HBr, 2.) 33percent NaOH / 1.) 75 deg C, 24 h, 2.) water, THF, rt, 94 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 15 p. 4010 - 4012
反应条件
1: H2 / Pd, C (5percent) / toluene / 24 h / 15200 Torr / Ambient temperature 2: 1.) 48percent aq. HBr, 2.) 33percent NaOH / 1.) 75 deg C, 24 h, 2.) water, THF, rt, 94 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 15 p. 4010 - 4012
反应条件
1: 67 percent / CrO3/Py, Celite / CH2Cl2 / 0.5 h / -10 °C 2: 1.) LDA / 1.) THF, hexane, below -75 deg C, 10 min, 2.) 12 min 3: 86 percent / aq. 1 M NaOH / dioxane / 1 h / Ambient temperature; pH 12.0-12.2 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 47, # 15 p. 3016 - 3018
反应条件
1: toluene / 4 h 2: 91 percent / 6N HCl / diethyl ether / Ambient temperature 3: NaBH4 / methanol 4: H2 / 10 percent Pd/C / methanol 5: DMAP / CHCl3 6: 89 percent / 1N NaOH / dioxane View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 4 p. 775 - 776
反应条件
1: NaBH4 / methanol 2: H2 / 10 percent Pd/C / methanol 3: DMAP / CHCl3 4: 89 percent / 1N NaOH / dioxane View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 4 p. 775 - 776
反应条件
1: H2 / 10 percent Pd/C / methanol 2: DMAP / CHCl3 3: 89 percent / 1N NaOH / dioxane View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 4 p. 775 - 776
反应条件
1: 91 percent / 6N HCl / diethyl ether / Ambient temperature 2: NaBH4 / methanol 3: H2 / 10 percent Pd/C / methanol 4: DMAP / CHCl3 5: 89 percent / 1N NaOH / dioxane View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 4 p. 775 - 776
反应条件
1: 84 percent / TiCl4 / CH2Cl2 / 1.83 h / -78 °C 2: 1.) O3, Me2S, 2.) PCC / 1.) 3:1:3 CH2Cl2-MeOH-pentane, -78 deg C, 2.) CH2Cl2, 0 deg C, 8 h 3: 1.) 1.5 mol eq NaOH, 2.) HCl / 1.) H2O-dioxan, 25 deg C, 28 h, 2.) -5 deg C View Scheme
参考文献
Tetrahedron Letters, , vol. 28, # 52 p. 6535-6538
反应条件
potassium hydroxide in methanol T=50°C; 3.75 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Synthesis, , # 12 p. 951 - 953
反应条件
1.1: 90 percent / TBAF / tetrahydrofuran / 12 h / 60 °C 2.1: aq. HCl / tetrahydrofuran / 12 h / 120 °C 2.2: 93 percent / aq. NaHCO3 / methanol / 2 h / 20 °C View Scheme
参考文献
Synthesis, , # 14 p. 2161 - 2164
